Introduction:
Pharmacogenomics is the study of how genes affect an individual’s response to drugs. This is a new field that combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop fruitful, safe medicines and doses that will be customized to a human genetic makeup.
Now drugs that are available are “one size fits all,” but they do not effective for every person. It is very tough to augur that a person get benefit from drug or not, and whether the drug has a side effects .Negative side effects of medicine cause a lot of death in US. After studying Human Genome Project researchers start learning how inherited differences in genes affect the human body’s internal response to drugs. These …show more content…
When a gene variant is associated with a specific drug response in a patient, there is the possibility of making clinical conclusion based on genetics by accommodating the amount of drug or selecting a different medicine, for example. Scientists analyse various gene affecting a person reaction to a drug similarly they also determine gene variants connected with diseases: by identifying position of gene linked with familiar drug responses, and then testing individuals whose response is unknown. Modern perspective contain multigene analysis, and these are just coming into clinical use for discovery of new medicines and their …show more content…
The technical terms for these two determinants are
• pharmacokinetics
• Pharmacodynamics Both these terms are critical reviews in the field of pharmacogenomics.
Pharmaco-kinetics:
Pharmacokinetics consist of four major processes: absorption, distribution, metabolism, and excretion, which are termed as ADME.
• Absorption usually deal with how a drug invade into bloodstream of an individual after taking it as a tablet or take it as an inhalant, intravenous injection evade absorption by giving a drug directly into the human blood.
• Distribution narrate that after first process that is absorption ,in which where pills travel and amount that comes at target area. Many drugs, for example, cannot pass the blood-brain barrier.
• Metabolism describes how drug worn out into the body of an individual, which occur instantly with the help of enzymatic action which is present in stomach and sometimes include final products with their own pharmacologic action.
• In the end excretion tells us the way by which drug remove from the body and the method may be urine, bile, and some time
Pharmacogenomics is the study of how genes affect an individual’s response to drugs. This is a new field that combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop fruitful, safe medicines and doses that will be customized to a human genetic makeup.
Now drugs that are available are “one size fits all,” but they do not effective for every person. It is very tough to augur that a person get benefit from drug or not, and whether the drug has a side effects .Negative side effects of medicine cause a lot of death in US. After studying Human Genome Project researchers start learning how inherited differences in genes affect the human body’s internal response to drugs. These …show more content…
When a gene variant is associated with a specific drug response in a patient, there is the possibility of making clinical conclusion based on genetics by accommodating the amount of drug or selecting a different medicine, for example. Scientists analyse various gene affecting a person reaction to a drug similarly they also determine gene variants connected with diseases: by identifying position of gene linked with familiar drug responses, and then testing individuals whose response is unknown. Modern perspective contain multigene analysis, and these are just coming into clinical use for discovery of new medicines and their …show more content…
The technical terms for these two determinants are
• pharmacokinetics
• Pharmacodynamics Both these terms are critical reviews in the field of pharmacogenomics.
Pharmaco-kinetics:
Pharmacokinetics consist of four major processes: absorption, distribution, metabolism, and excretion, which are termed as ADME.
• Absorption usually deal with how a drug invade into bloodstream of an individual after taking it as a tablet or take it as an inhalant, intravenous injection evade absorption by giving a drug directly into the human blood.
• Distribution narrate that after first process that is absorption ,in which where pills travel and amount that comes at target area. Many drugs, for example, cannot pass the blood-brain barrier.
• Metabolism describes how drug worn out into the body of an individual, which occur instantly with the help of enzymatic action which is present in stomach and sometimes include final products with their own pharmacologic action.
• In the end excretion tells us the way by which drug remove from the body and the method may be urine, bile, and some time