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16 Cards in this Set
- Front
- Back
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What is a drug used exclusively for absence seizure treatment?
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Ethosuxamide
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Outline the 4 ways that most antiepeleitic drugs.
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Na2+ channel inactivation, Reduced Ca2+ intake, Increased GABA release, Decreased Glutamate release
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When selecting an antiepeleptic initially, what should be your two primary considerations?
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Type of siezure and cost
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What drugs are used to treat only partial seizures?
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Carbamazepine, Gapapentin, Phenytoin, Tigabine, Phenobarbital
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What drugs are considered broad spectrum antiepeleptics?
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Valproate, Lamotrigine, Topiramate, Zonisamide
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Generally, the side effects of anti-epeleptics are all the same, list 3.
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Impaired congnition, somnolence, weight changes
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What are 3 toxic effects of antiepeleptics?
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Teratogenicity, Anemia, Liver failure
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List 2 reasons why Phenytoin is bad
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its a CYP enzyme inducer, it is unpredictable
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What antiepeleptics are CYP inducers
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phenytion, carbamazepine, phenobarbital, primadone (3A4, UGT, 2C, 1A2)
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Generally, how are older antiepeleptics eliminated? Newer?
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Older are hepatic newer are more renal (gabapentin, topiramate, and vigabatrin are almost completely renal)
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What anti epileptics have a high probability of drug-drug interaction?
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phenytoin, carbamazepine, valproate, phenobarbital, primidone, felbamate
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What anti epileptics have a low probability of drug-drug interaction?
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gabapentin, pregabalin, levetiracetam, ethosuximide, vigabatrin
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What anti epileptics have a high probability of causing a rash
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phenytoin, carbamazepine, oxcarbazepine, phenobarbital, lamotrigine
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List 4 first line anti epileptics for partial seizures
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lamotrigine, oxcarbamazepine, carbamazepine (the toyota), levetiracetam
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List 3 first line anti epileptics for idiopathic generalized epilepsy
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Valproate (not as good in females as it is a terratogen), Lamotrigine, Levetiracetam
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List 2 first line anti epileptics for childhood absence seizure
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Valproate, ethosuxamide
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