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10 Cards in this Set
- Front
- Back
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What are the indications of aspirin as an antiplatelet agent?
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ACS, stroke, arterial thrombosis
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What is the end product blocked by aspirin
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Thromboxane A2 (via COX1)
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What are the indications of Clopidogrel?
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ACS, stroke, stent, thrombosis
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What is the mechanism of Clopidogrel
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ADP receptor antagonist, reducing GPIIb/IIIa expression
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What is a non bleeding side effect of Clopidogrel?
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TTP , due to underlying vWF deffiency
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What are the 3 direct GPIIb/IIIa inhibitors?
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Abciximab
Tirofiban Epifibtamide All three drugs are reversible |
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What is the effect of Dipyramidole and Cilostazol?
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PDE-3 inhibition (this keeps cAMP high in the platelets and blocks the expression of GP IIIb/IIIa
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What are the indications of a GP IIb/IIIa blocker?
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ACS, PCI
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What are the indications of Cilostazol?
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PVD, Claudication (similar things really)
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What are the indications of Dipyramidole?
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Arterial thrombosis, Stroke
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