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29 Cards in this Set

  • Front
  • Back
Generally, how are Malarias treated?
You try and prevent first, then you use the CDC data for the regional strains.
What are the primary anti-malarials?
Chloroquine
Primaquine
Mefloquine
Quinine (Severe Disease)
What is used to treat P. falciprum?
Mefloquine, there is a lot of Chloroquine resistance
What are the side effects of Chloroquine?
Puritis, nausea, vomiting, malaise
What is used popularly for Malaria prophylaxis?
Mefloquine
What are the side effects of Mefloquine?
Siezures, sleep problems, arrhythmias
What is used to treat the exoerythrocytic phase of malaria?
Primaquine
What are the side effects of Primaquine?
Nausea, cramps, Rarely - hemolysys (G6PD deficiency) and arrythmeas
What is used to treat tissue Amebiasis?
Metronidazole
What is used to treat luminal Amebiasis?
Iodoquinol (DOC)
Paromomycin
Diloxanide Furoate
What is used to treat African Trypanosomiasis?
Hemolymphatic:
Pentamadine
Suramin

CNS:
Melarsoprol
Eflornithine
What are the drawbacks to the drugs used to treat Trypaosomiasis?
They are extremely dangerous! Extreme fatigue nausea, vomiting, parastesia, nephrotoxic,

Pentamadine is Pancreaotoxic as well

The CNS drugs can cause seizures, arthralgias, even death (Melarsoprol is the worst)
What is used to treat American Trypanosomiasis?
Nifurtimox
Benznidazole
What is the draw back to these American Trypanosomiasis treatments?
They are not effective against chronic stages
What are the major side effects of Nifurtimox and Benznidazole
Neuropathies, insomnia, seizures
What is used to treat Leishmania?
Sodium Stibogluconate
What are the side effects of Sodium Stibogluconate?
Fever, myalgia, arthralgia (flu-like) prolonged QT
What are the drugs used to to treat Cryptosporidiosis?
Nitazoxanide (only in good CD4 counts)
Paromycin

Lactose-free diet, anti-motility agents
What are the drugs used to treat Giardiasis?
Metronidazole (DOC)
Nitazoxanide
What is used to treat Toxoplasmosis?
Pyrimethamine (combo with folinic acid, and clindamycin OR sulfadiazine)
What drugs are used to treat helminthic infections generally?
Albendazole
Mebendazole
Ivermectin
Praziquantel
What is particularly used to treat Neurocysticercosis?
Steroids, Anticonvulsants, Albendazole (or Praziquantel)
What is used to treat Trichanosis and Taeneasis?
Mebendazole
What are the side effects of Albenzazole?
Minimal, late in treatment may see elevated LFT's and GI effects

Meaning it is safe in pregnancy
What are the side effects and contraindications of Praziquantel
GI mostly

Contraindicated in ocular infections and pregnancy
What are the side effects and contraindications of Mebendazole?
GI generally, hypersensitivity

Contraindicated in 1st trimester and under 2 years of age

Interacts with Neuroleptics
What are the indications of Ivermectin?
Strongylodiasis, Onchocerciasis
What are the side effects and contraindications for Ivermectin?
Not too many, hypersensitivity due to worm death

Contraindicated in pregnancy
What are the indications of DEC (diethylcarbamazepine citrate)
Filarosis
Loiasis
Tropical Eocinophillia
W. bancrofti (with Iver)