Pharmacology 24 Drugs That Treat Mild To Moderate Pain, Fever, Inflammation, & Migraines

Front 1

(P) ASPIRIN

Back 1

SALICYLATE

4:
mild-moderate pain analgesic, antipyretic, anti-inflammatory, anti-platelet
irreversibly inhibits COX (cyclooxegenase)

MECH:
Fever: inhibits PGE2 synth in hypothalmus
inflamm: inhibits prostaglandin
anti-platelet: irrev inhibits Thromboxane A2

CONTRAS:
Peptic Ulcer
Gout
renal / heptic impairmnt
bleeding dis
on anti-coag thrpy

ADVERSES:
GI probs
RENAL IMPAIR
GASTRIC ULCERS
GI BEED

**NOt 4 kids w/ varicella (REYE'S!!), NOT during preg (esp. 3rd trim)**

** give w/ milk / food**

**<81 mg UNcoated daily = for +CV effects**

Front 2

(P) IBUPROFEN

Back 2

NSAID (Non-steroidal anti-inflammatory)

4:
arthritis
mild - moderate pain
1o dysmenorrhea
migraine

anti-inflammation, analgesic, anti-pyretic, reversibly inhibits COX (cyclooxygenase)

MECH:
Inhibits COX & Prostaglandin - absorbed from GI

CONTRAS:
active GI dis
renal / hepatic impair
hemetopoetic dysfunc
pts on coagulotherapy
NSAIDs - BLACK BOX: MI / STROKE

ADVERSES:
GI probs
Hepatic / renal toxicity

** preg cat D (3rd tri)**

** MONITOR elderlies**

**give w/ milk / food**

Front 3

(P) ACETAMINOPHEN

Back 3

PARA-AMINOPHENOL DERIVATIVE

4:
mild pain
anti-pyretic

MECH:
Central - inhibits prostaglandin synthesis in CNS

CONTRAS:
hepatic dis
viral hepatitis
alcoholism

ADVERSES:
OD = fatal
rash
urticaria (hives)
HEPATIC / RENAL TOXICITY

**drug of choice 4 kids & pregs**

**ACETYLCYSTEINE = antidote**

**interacts w/ warfarin (coumadin)**

Front 4

(P) SUMATRIPTAN

Back 4

SEROTONIN SELECTIVE AGONIST

4:
acute migraine (1o line)
cluster headA

MECH:
selects: 5-HT1b/1d reecpts in cranial blood vessels & sens nerves of trigemenovasc sys = vasoconstric

CONTRAS:
coronary artery dis
ischemic cardiac dis
CbV dis (cerebrovasc)

ADVERSES:
CNS: flush / dizzy / wknss /
VASOSPADM -> ISCHEMIA IN CV & CbV sys
dysrrhythmias
angina

**give @ beg in headA**

**doesn't help with other HeadA types**