Phar 321 - Solid Oral Dosage Forms

Front 1

What are types of solid oral dosage forms? (3)

Back 1

1. Capsules

2. Powders

3. Tablets

Front 2

What are some advantages for solid oral dosage forms for patients? (4)

Back 2

1. Non-invasive

2. Easy to take

3. Portable

4. Palatable

Front 3

What are some disadvantages for solid oral dosage forms for patients? (2)

Back 3

1. Some drugs cause GI irritation

2. Big tablets can be hard to swallow

Front 4

What are some advantages for solid oral dosage forms for manufacture? (4)

Back 4

1. Easy to make/ well established methods

2. Accurate dosing

3. Drug stability

4. Easy to pack, ship, and store

Front 5

What are some disadvantages for solid oral dosage forms for manufacture? (2)

Back 5

1. Some drugs poorly soluble in aqueous setting
2. Some drugs have poor bioavailability

Front 6

What are characteristics of a good tablet formation? (6)

Back 6

1. Stable

2. Accurate dosing

3. Consistent performance and pharmacokinetics

4. Easy to pack, ship, and store

5. Palatable

6 Pharmaceutically elegant

Front 7

Define: excipients

Back 7

Pharmacologically inactive substances added to the API to improve or modify:

• bioavailability
• stability
• manufacturing
• drug release
• flavour
• performance

Front 8

Define: diluents

Back 8

Substances used to dilute or increase bulk volume of tablets for ease of handling.

Front 9

What are characteristics of a good diluent? (7)

Back 9

1. Chemically inert

2. Hydrophilic/ water soluble

3. Palatable

4. Non-hygroscopic

5. Cheap

6. Compactible

7. Biocompatible

Front 10

Define: binders

Back 10

A glue/ substance that helps granules and tablets compress into a stable tablet.

Front 11

Define: disintegrants

Back 11

Substances used to help with tablet fragmentation upon ingestion.

Front 12

MOA of disintegrants? (2)

Back 12

1. Help with water uptake to wet drug particles

2. Swelling of disintegrants causes tablet rupture

Front 13

Define: lubricants

Back 13

Added to ensure tablet formation and ejection can occur without friction, to prevent capping, fragmentation, and scratches.

They are typically hydrophobic.

Front 14

Define: glidants

Back 14

Used to improve flow of powder or granules. Sufficient flow is needed for high speed mass manufacturing.

Front 15

Define: colorants

Back 15

Used for pharmaceutical elegants

Front 16

What do you call a dog with no legs?

Back 16

It doesn't matter, it won't come.

Front 17

Define: Flavouring

Back 17

Used to enhance palatability

Front 18

Acacia

Back 18

Binder

Front 19

Calcium carbonate

Back 19

Diluent

Front 20

Calcium phosphate

Back 20

Diluent

Front 21

Carnauba wax

Back 21

Binder

Front 22

Cellulose

Back 22

Diluent

Disintegrant

Front 23

Citric acid

Back 23

Flavourant

Front 24

Colloidal silicon dioxide/ colloidal silicon

Back 24

Glidant

Front 25

Confectioner's (Icing) sugar

Back 25

Flavourant

Front 26

Crosscarmelose

Back 26

Disintegrant

Front 27

Crosspovidone

Back 27

Disintegrant

Front 28

D&C Blue No. 2

Back 28

Colorant

Front 29

D&C Red No. 7

Back 29

Colorant

Front 30

D&C Yellow No. 6

Back 30

Colorant

Front 31

Gelatin

Back 31

Binder

Front 32

If there's H2O on the inside of a fire hydrant, what's on the outside?

Back 32

K9P

Front 33

Glucose

Back 33

Diluent

Front 34

Hydroxypropylmethyl cellulose

Back 34

Binder

Front 35

Lactose

Back 35

Diluent

Front 36

Paraffin

Back 36

Lubricant

Front 37

Magnesium stereate

Back 37

Lubricant

Glidant

Front 38

Mannitol

Back 38

Diluent

Front 39

Microcrystalline cellulose

Back 39

Binder

Front 40

Polyethylene Glycol (PEG)

Back 40

Binder

Lubricant

Front 41

Polyvinylpyrrilidone (PVP)

Back 41

Binder

Front 42

Sodium lauryl sulfate

Back 42

Lubricant

Front 43

Sodium starch glycolate

Back 43

Disintegrant

Front 44

Sodium stearyl fumarate

Back 44

Lubricant

Front 45

Sorbitol

Back 45

Diluent

Front 46

Starch

Back 46

Binder

Disintegrant

Front 47

Stearic acid

Back 47

Lubricant

Front 48

Sucrose

Back 48

Diluent

Binder

Front 49

Talc

Back 49

Glidant

Front 50

Tapioca starch

Back 50

Binder