Pantoprazole undergoes hepatic first pass metabolism , hence it shows poor bioavailability. The aim of study was to prepare and evaluate mucoadhesive tablet of pantoprazole using tamarind seed powder in combination with HPMC, magnesium oxide, and talc. Tamarind seed powder is used for dissolution enhancer (improve dissolution).
Method: Six Formulations were developed with varying concentration of polymer like HPMC and other excipients like tamarind seed powder, magnesium oxide and lactose.
Result: The formulations were evaluated for hardness, thickness, surface pH, weight variation, content uniformity, and swelling index. The maximum in vitro drug profile was achieved with the formulation F4 which contain drug , tamarind seed powder, …show more content…
The Xmax of the drug was determined by scanning above solution between 400 and
200 nm using UV –visible spectrophotometer.
i) In 0.1 N HCL : Drug is calibrated in 0.1 N HCL by using UV spectrophotometer at determined wavelength.
ii) In PH 6.8 Phosphate buffer: Drug in calibrated in PH 6.8 Phosphate buffer by using UV-spectrophotometer at determined wavelength.
Preparation of mucoadhesivebuccal tablet.
Mucoadhesivebuccal tablet, each containing 20 mg Pantoprozle sodium sequihydrate (PSS) Were prepared by direct compression method . Composition of various formulations employing tamarind powder ,HPMC , Magnesium oxide and lactose are very important in the formulation . To determine the effect of selected exciplent on the release of pantoprazole six formulations were formed all the batches were prepared which is show in table I.
All the ingredients of tablets were blended in glass mortar with a pestle for 15 min and pass through sieve no 85 to obtain uniform mixture . The blended powder was then compressed into 100 mg tablets on a single stoke, 10 station rotary tablet machine with 6mm round shaped flat punch .
Ingredients (mg)/ Formulations F1
F2 …show more content…
The maximum and minimum average thickness of tablet was found to 2.26 mm and 2.13 mm. None of the formulation deviated from the standards.
Friability
Percentage weight loss in friability test was in the range 0.1% to 0.5% in nine batches prepared by direct compression. The experiment was performed in triplicate and average value was calculated.
Content uniformity :
The content uniformity of the entire tablet (F1 to F6) was evaluated and the results are presented in following table. The maximum and minimum percentage of drug content from the different formulations was found to be 95.56 and 91.92 % respectively.
Surface pH
The surface pH of tablets of each formulation (F1 to F6) was tested and the results are provided in following table. The maximum and minimum pH value of the formulations were found to be 7.1 to 6.9 respectively. The acceptable pH of saliva is in the range of 5-7 and surface pH of all tablets is within limit. Hence the formulations may not produce any irritation to the buccal mucosa.
Weight variation :
Weight variation of tablets of each formulation (F1 to F6) was tested and the results are provided in following table. The weight variation of each batch of tablet ranged from 99.33 to
Method: Six Formulations were developed with varying concentration of polymer like HPMC and other excipients like tamarind seed powder, magnesium oxide and lactose.
Result: The formulations were evaluated for hardness, thickness, surface pH, weight variation, content uniformity, and swelling index. The maximum in vitro drug profile was achieved with the formulation F4 which contain drug , tamarind seed powder, …show more content…
The Xmax of the drug was determined by scanning above solution between 400 and
200 nm using UV –visible spectrophotometer.
i) In 0.1 N HCL : Drug is calibrated in 0.1 N HCL by using UV spectrophotometer at determined wavelength.
ii) In PH 6.8 Phosphate buffer: Drug in calibrated in PH 6.8 Phosphate buffer by using UV-spectrophotometer at determined wavelength.
Preparation of mucoadhesivebuccal tablet.
Mucoadhesivebuccal tablet, each containing 20 mg Pantoprozle sodium sequihydrate (PSS) Were prepared by direct compression method . Composition of various formulations employing tamarind powder ,HPMC , Magnesium oxide and lactose are very important in the formulation . To determine the effect of selected exciplent on the release of pantoprazole six formulations were formed all the batches were prepared which is show in table I.
All the ingredients of tablets were blended in glass mortar with a pestle for 15 min and pass through sieve no 85 to obtain uniform mixture . The blended powder was then compressed into 100 mg tablets on a single stoke, 10 station rotary tablet machine with 6mm round shaped flat punch .
Ingredients (mg)/ Formulations F1
F2 …show more content…
The maximum and minimum average thickness of tablet was found to 2.26 mm and 2.13 mm. None of the formulation deviated from the standards.
Friability
Percentage weight loss in friability test was in the range 0.1% to 0.5% in nine batches prepared by direct compression. The experiment was performed in triplicate and average value was calculated.
Content uniformity :
The content uniformity of the entire tablet (F1 to F6) was evaluated and the results are presented in following table. The maximum and minimum percentage of drug content from the different formulations was found to be 95.56 and 91.92 % respectively.
Surface pH
The surface pH of tablets of each formulation (F1 to F6) was tested and the results are provided in following table. The maximum and minimum pH value of the formulations were found to be 7.1 to 6.9 respectively. The acceptable pH of saliva is in the range of 5-7 and surface pH of all tablets is within limit. Hence the formulations may not produce any irritation to the buccal mucosa.
Weight variation :
Weight variation of tablets of each formulation (F1 to F6) was tested and the results are provided in following table. The weight variation of each batch of tablet ranged from 99.33 to