1. Amlodipine is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as long acting dihydropyridine-type calcium channel blockers. Amlodipine widen the blood vessels and improves blood flow. Widening of these blood vessels lowers blood pressure. In angina, amlodipine increases blood flow to the heart muscle to relieve pain due to angina. (WHO, 2013). Amlodipine was discovered by a research team lead by Simon Campbell and created by the Pfizer Corporation. Amlodipine was introduced in the United State in 1992. Just two years after its discovery in 1994 the sale of amlodipine achieved a plateau of 2,000,000 new prescriptions per year (Davies et al, 2005).
2. The slow rate of elimination (eliminate half-life of 40-60 h) give a few pharmacokinetic attributes that are not seen with other calcium-antagonist drugs. Alteration of plasma drug concentration between doses is between 20 and 25% when once-daily dosing is used. Onset of effect is gradual after oral administration which is due to moderate rate of drug absorption and maybe also to the …show more content…
The physiochemical properties of this combination tablets were assessed through the evaluation of uniformity of tablet weight, thickness test, hardness test, friability test,disintegration test, dissolution test and potency test according to the standard method. They have generally two type of test. First compendial test and another one in non compendial test. Compendial tests are test methods that are described in the pharmacopoeias like United States Pharmacopeia (USP), British Pharmacopoeia (BP) etc. They are also known as official tests. They include weight variation test, disintegration test, dissolution test and drug content test. While, non-compendial test: These tests methods are not defined in any pharmacopeias and so they were referred as Non-Compendial Tests or unofficial tests which include friability test, hardness test and thickness test (Shohin et al,
2. The slow rate of elimination (eliminate half-life of 40-60 h) give a few pharmacokinetic attributes that are not seen with other calcium-antagonist drugs. Alteration of plasma drug concentration between doses is between 20 and 25% when once-daily dosing is used. Onset of effect is gradual after oral administration which is due to moderate rate of drug absorption and maybe also to the …show more content…
The physiochemical properties of this combination tablets were assessed through the evaluation of uniformity of tablet weight, thickness test, hardness test, friability test,disintegration test, dissolution test and potency test according to the standard method. They have generally two type of test. First compendial test and another one in non compendial test. Compendial tests are test methods that are described in the pharmacopoeias like United States Pharmacopeia (USP), British Pharmacopoeia (BP) etc. They are also known as official tests. They include weight variation test, disintegration test, dissolution test and drug content test. While, non-compendial test: These tests methods are not defined in any pharmacopeias and so they were referred as Non-Compendial Tests or unofficial tests which include friability test, hardness test and thickness test (Shohin et al,