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33 Cards in this Set

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Most common primary Malignant tumor of the bone
Osteosarcoma
Malignant bone tumor with peak incidence in Men ages 10-20; most commonly found in the Metaphysis of long bones
Osteosarcoma
X-ray findings:
-Codman's triangle
-"sunburst" pattern

Lab: increased serum Alk Phos
Osteosarcoma
What are the risk factors for Osteosarcoma? (6)
1. Paget disease
2. Fibrous dysplasia
3. Ionizing radiation
4. Familial Retinoblastoma
5. Bone infarcts
6. p53 mutations
Osteosarcoma
-metaphysis of long bones
This came from a 17 year old male with elevated Serum Alk Phos. Dx?
Osteosarcoma
-Metaphysis of tibis
-Codman's triangle = elevation of the Periosteum
What malignant bone tumor is this?
Osteosarcoma
-anaplastic Osteoblasts producing Osteoid (light pink) & Bone (black)
What malignant bone tumor is this?
Osteosarcoma
-anaplastic Osteoblasts producing Osteoid & Bone
What malignant bone tumor is this?
What is a common metastatic site of Osteosarcoma's?
Hematogenous spread to Lungs
Malignant Cartilaginous tumor of chondroblasts
Chondrosarcoma
What gender & age group are Chondrosarcoma's most common in?
Males age 30-60
Chondrosarcoma
-Punctate calcifications = cortex is being pushed out
-is a glistening mass within the medullary cavity
This is from a 13 year old boy with an enlarging mass with pain & swelling
Chondrosarcoma
-malignant cartilaginous tumor
What malignant bone tumor?
Chondrosarcoma
-nodes of disordered cartilage
What malignant bone tumor is this from?
Chondrosarcoma
-atypical chondrocytes & chondroblasts with multiple nuclei in a Lacuna
What malignant bone tumor is this from?
Chondrosarcoma = cartilaginous tumor

Punctate calcifications

Usually occurs in central bones = pelvis, spine, scapula
What malignant bone tumor is this from? How do you know? What is atypical?
Malignant bone tumor associated with a chromosomal translocation t(11;22)
Ewing Sarcoma
What are Ewing Sarcoma's derived from?
Neuroectoderm
11 year old boy with a painful, swollen, enlarging mass on his right leg. Has leukocytosis & elevated ESR. What malignant bone tumor?
Ewing Sarcoma
Anaplastic small blue cell malignant bone tumor
Ewing Sarcoma
"onion-skin" appearance on X-ray
Ewing Sarcoma

"going out for eWINGS & ONION rings"
Ewing Sarcoma
-arises within the marrow cavity
Extremely aggressive malignant bone tumor with early metastasis that arises from Neuroectoderm
Ewing Sarcoma

Labs: leukocytosis (fever); elevated ESR
What malignant bone tumor is this?

What lab findings may be present?
Ewing Sarcoma
-sheets of undifferentiated small round blue cells
-Neuroectodermal in origin
-Homer Wright pseudorosettes
What malignant bone tumor is this?
Ewing Sarcoma
-cytoplasm filled with Glcogen (red on left pic)
What malignant bone tumor did this come from?
What is the treatment for Ewing Sarcoma?
Chemotherapy + Surgery &/or Radiation
What are the most common sites of Ewing Sarcoma?
Femur

Pelvis

Tibia
Malignant Fibrous Histiocytoma of bone
-can arise anywhere = Epiphysis, Metaphysis, Diaphysis
-Slower growing than Osteosarcoma
-can occur at any age
Dx???
Malignant Fibrous Histiocytoma
What are these showing?
Malignant Fibrous Histiocytoma
What is this?
Malignant Fibrous Histiocytoma
-Storiform pattern = cartwheel arrangement
What is this?
Malignant Fibrous Histiocytoma
What is this?
Malignant Fibrous Histiocytoma
-histiocytes with typical abundant foamy looking cytoplasm
What is this?