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33 Cards in this Set
- Front
- Back
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Most common primary Malignant tumor of the bone
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Osteosarcoma
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Malignant bone tumor with peak incidence in Men ages 10-20; most commonly found in the Metaphysis of long bones
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Osteosarcoma
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X-ray findings:
-Codman's triangle -"sunburst" pattern Lab: increased serum Alk Phos |
Osteosarcoma
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What are the risk factors for Osteosarcoma? (6)
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1. Paget disease
2. Fibrous dysplasia 3. Ionizing radiation 4. Familial Retinoblastoma 5. Bone infarcts 6. p53 mutations |
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Osteosarcoma
-metaphysis of long bones |
This came from a 17 year old male with elevated Serum Alk Phos. Dx?
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Osteosarcoma
-Metaphysis of tibis -Codman's triangle = elevation of the Periosteum |
What malignant bone tumor is this?
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Osteosarcoma
-anaplastic Osteoblasts producing Osteoid (light pink) & Bone (black) |
What malignant bone tumor is this?
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Osteosarcoma
-anaplastic Osteoblasts producing Osteoid & Bone |
What malignant bone tumor is this?
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What is a common metastatic site of Osteosarcoma's?
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Hematogenous spread to Lungs
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Malignant Cartilaginous tumor of chondroblasts
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Chondrosarcoma
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What gender & age group are Chondrosarcoma's most common in?
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Males age 30-60
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Chondrosarcoma
-Punctate calcifications = cortex is being pushed out -is a glistening mass within the medullary cavity |
This is from a 13 year old boy with an enlarging mass with pain & swelling
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Chondrosarcoma
-malignant cartilaginous tumor |
What malignant bone tumor?
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Chondrosarcoma
-nodes of disordered cartilage |
What malignant bone tumor is this from?
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Chondrosarcoma
-atypical chondrocytes & chondroblasts with multiple nuclei in a Lacuna |
What malignant bone tumor is this from?
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Chondrosarcoma = cartilaginous tumor
Punctate calcifications Usually occurs in central bones = pelvis, spine, scapula |
What malignant bone tumor is this from? How do you know? What is atypical?
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Malignant bone tumor associated with a chromosomal translocation t(11;22)
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Ewing Sarcoma
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What are Ewing Sarcoma's derived from?
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Neuroectoderm
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11 year old boy with a painful, swollen, enlarging mass on his right leg. Has leukocytosis & elevated ESR. What malignant bone tumor?
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Ewing Sarcoma
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Anaplastic small blue cell malignant bone tumor
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Ewing Sarcoma
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"onion-skin" appearance on X-ray
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Ewing Sarcoma
"going out for eWINGS & ONION rings" |
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Ewing Sarcoma
-arises within the marrow cavity |
Extremely aggressive malignant bone tumor with early metastasis that arises from Neuroectoderm
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Ewing Sarcoma
Labs: leukocytosis (fever); elevated ESR |
What malignant bone tumor is this?
What lab findings may be present? |
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Ewing Sarcoma
-sheets of undifferentiated small round blue cells -Neuroectodermal in origin -Homer Wright pseudorosettes |
What malignant bone tumor is this?
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Ewing Sarcoma
-cytoplasm filled with Glcogen (red on left pic) |
What malignant bone tumor did this come from?
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What is the treatment for Ewing Sarcoma?
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Chemotherapy + Surgery &/or Radiation
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What are the most common sites of Ewing Sarcoma?
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Femur
Pelvis Tibia |
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Malignant Fibrous Histiocytoma of bone
-can arise anywhere = Epiphysis, Metaphysis, Diaphysis -Slower growing than Osteosarcoma -can occur at any age |
Dx???
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Malignant Fibrous Histiocytoma
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What are these showing?
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Malignant Fibrous Histiocytoma
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What is this?
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Malignant Fibrous Histiocytoma
-Storiform pattern = cartwheel arrangement |
What is this?
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Malignant Fibrous Histiocytoma
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What is this?
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Malignant Fibrous Histiocytoma
-histiocytes with typical abundant foamy looking cytoplasm |
What is this?
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