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21 Cards in this Set
- Front
- Back
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Monobactam |
Its representative drug is Aztreonam |
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Penicillin-binding protein 3 |
This is the protein that monobactam prefers to bind to. |
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Monobactamic acid |
General nucleus of monobactam |
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Aztreonam |
Administered by IV, renally eliminated, adverse effects are GI upset, vertigo and headache |
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Carbapenems |
Active against G(+) cocci, G(-) rods, anaerobes, P. Aeruginosa and Acineto bacter |
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Carbapenems |
Drugs of choice for Enterobacter, Citrobacter, and Serratia |
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Cilastatin |
A renal dehydropeptidase I that raises imipenem levels |
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Seizures |
Adverse effect of imipenem |
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Ertapenem |
Its adverse effect is pain at the injection site |
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Vancomycin, Daptomycin, Bacitracin |
Three drugs under the Peptides antibiotics |
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Vancomycin |
Glycopeptide that binds to the D-Alka-D-Ala terminals to inhibit transglycosylation |
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Vancomycin |
Not effective to resistant enterococci and S. Aureus but works against MRSA, C. difficile and penicillin resistant pneumococci (PRSP) |
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Daptomycin |
Cyclic lipopeptide with vancomycin-like activity but works against resistant enterococci and S. Aureus |
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Bacitracin |
Used only topically because of nephrotoxicity |
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Bacitracin |
Interferes with a late stage in cell wall synthesis for G(+) organisms |
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Daptomycin |
Peptide antibiotic that causes myopathy |
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Cycloserine |
Blocks incorporation of D-Ala into the side chain of peptidoglycan |
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Cycloserine |
An antimetabolite antibiotic used as a 2nd line treatment for TB |
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Neurotoxicity |
Caused by Cycloserine |
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Fosfomycin |
Used for UTI, it prevents formatiom of N-acetylmuramic acid by inhibiting enolpyruvate transferase |
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B-lactams, quinolones |
Two classes of drugs that Fosfomycin is synergistic with |
