Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
4 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
Examples are |
Imipenem Meropenem Doripenem Ertapenem |
Imipenem is compounded with cilastatin to protect it from metabolism by renal dehydropeptidase |
|
|
Imipenem resists hydrolysis by most beta lactamases but not the metallo -beta lactamases. |
They are useful in empiric therapy cos they are active against beta lactamase producing gram positive and gram negative organisms, anaerobes and P. aeruginosa. |
Meropenem and doripenem have similar activity with imipenem |
|
|
Pk of Carbapenems |
Administration :Imipenem/cilastatin and meropenem are administered IV
Distribution : Imipenem/cilastatin and meropenem penetrate well into the tissues and fluids including csf when the meninges are inflamed. Meropenem reach therapeutic levels in the bacterial meningitis even without inflammation Elimination : by Glomerular filtration |
Mummy mu oo |
|
|
Contraindications : should be adjusted with caution in patients with renal insufficiency |
Adverse effects : Imipenem /cilastatin can cause nausea Vomiting Diarrhea High levels of imipenem= cause seizures |
Thank you |
