Mrcp Part 2 - Neurology

Front 1

Sporadic CJD

Back 1

CSF analysis of protein 14.3.3 and RTQuIC

Front 2

Hippel-Lindau syndrome

Back 2

Retinal angioma

CNS haemangioblastoma

Phaechromocytoma

Renal cell carcinoma

Front 3

Fabry disease

Back 3

Pain - extremeties + GI tract

Kidney - failure

Heart - many ways

Skin - angiokeratoma in lower body

Eye - whorl-like cornea

CNS - early stroke

Front 4

Myotonic dystrophy

Back 4

Cataracts (blue dot)

Early balding

Hypersomnia

Conduction problem

Insulin resistance

Front 5

Hashimoto's encephalopathy

Back 5

Ataxia

Dementia

Myoclonic jerk when startled

Non-specific EEG

Front 6

BIH/IIH

Back 6

Diagnosis: Lumbar puncture opening pressure >25

Treatment: acetazolamide, bariatric surgery for weight loss

Front 7

Diabetic amyotrophy

Back 7

Proximal weakness

Minimal sensory loss

Front 8

Alcoholic and unresponsive

Back 8

CT head - rule out subdural haematoma

Front 9

Refsum disease

Back 9

Autosomal recessive

Raised phytanic acid

Night blindness (retinitis pigmentosa)

Shortening of fourth toe (epiphyseal dysplasia)

Front 10

EEG findings

Back 10

HSV encephalitis - frontotemporal slowing with periodic sharp wave complexes

Front 11

Circle of Willis and vascultare

Back 11

Anterior circulation - MCA, ACA, anterior choroidal artery

Posterior circulation - vertebral artery, basilar artery, PCA

Hint 11

Front 12

MS drugs MOA

Back 12

Fingolimod - modulates S1P receptor to prevent lymphocyte migration across BBB

Glatiramer - mimics myelin peptide, competes with myelin antigen for their presentation to T cells

Ocrelizumab - B-cell cytotoxic

Alemtuzumab - T-cell cytotoxic

Beta-interferons - increases anti-inflammatory agents, reduces number of inflammatory cells crossing BBB

Teriflunomide - active metabolite of leflunomide, inhibits pyrimidine synthesis

Front 13

Periodic paralysis

Back 13

Front 14

Paraganglioma

Back 14

Pulsatile tinnitus

X, XI, XII nerve lesions

Front 15

Cerebral sinus thrombosis

Back 15

Headache

Seizure

Raised ICP

Septic cause: otitis media, meningitis, facial cellulitis

Non-septic cause: pregnancy, thrombophilia, Behcet's

Absent delta sign (filling defect)

Treat with SC LMWH

Front 16

Parkinson's medication

Back 16

Front 17

Brachial neuritis

Back 17

Assumed immune mediated

Post-vaccination or illness

Short spell of shoulder pain that resolves

Followed by progressive weakness and wasting

Front 18

McArdle's disease

Back 18

Muscle pain with exercise

Dark urine (rhabdo)

Second wind phenomenon

Front 19

Botulism

Back 19

Descending paralysis starting with eye and bulbar muscles

Front 20

Neuroleptic malignant like syndrome

Back 20

Sudden withdrawal of levodopa in PD

Mildly raised creatinine

Front 21

Paroxysmal hemicrania

Back 21

Same symptoms as cluster headache but shorter (eg 2-25min) and more frequent attacks (50 attacks a day) and more common in females

Treatment: indometacin

Front 22

Rare forms of encephalitis

Back 22

Bickerstaff (?autoimmune)

- ataxia + ophthalmoplegia (just like Miller fisher)

- drowsiness/hyperreflexia

Limbic

- cognitive decline + seizure

- temporal lobe

- autoimmune/paraneoplastic

- treat with IVIg

Anti-NMDA

Rasmussen (paeds)

ADEM (paeds)

SSPE - caused by measles, always fatal

Front 23

Stroke distribution

Back 23

Front 24

Kearns-Sayre syndrome (mitochondrial disease)

Back 24

Ophthalmoplegia

Ptosis

Night blindness (retinitis pigmentosa)

Cerebellar syndrome

Sensorineural hearing loss

Front 25

Young patients with stroke

Back 25

ECHO - atrial septal aneurysm

Contrast ECHO (bubble test) - PFO

Front 26

IBM Vs paraneoplastic myopathy Vs polymyositis Vs alcohol related myopathy Vs MND

Back 26

Front 27

Paraganglioma of the head and neck

Back 27

Front 28

Tropical spastic paraparesis

Back 28

Afrocaribbean

HTLV-1 associated myelopathy

No cure

Front 29

Homocystinuria

Back 29

Marfan-like

Malar rash

Livedo reticularis

VTE

Lens dislocation (downward and inward)

Treat: B6(pyridoxine)

Front 30

Neurosarcoidosis

Back 30

Bilateral facial palsy

Optic nerve dysfunction

Papilloedema

Palate dysfunction

Meningitis

Myelopathy (spinal cord)

Front 31

Oculomasticarory myorhythmia

Back 31

Pathognomonic for Whipple's disease

Front 32

Tolosa-Hunt syndrome

Back 32

Caused by inflammation in cavernous sinus and superior orbital fissure

Unilateral headache

Painful ophthalmoplegia

Front 33

Myotomes

Back 33

Front 34

Dermatomes

Back 34

Front 35

Anterior circulation stroke

Back 35

Lacunar syndrome (most are caused by infarct of MCA branches)

Hint 35

Right MCA infarct involving inferior parietal lobe

Front 36

Hemiballismus

Back 36

Front 37

Posterior cerebral artery stroke - P1 syndrome

Back 37

Front 38

Posterior cerebral artery stroke - P2 syndromes

Back 38

Front 39

Cerebellar stroke syndromes

Back 39

PICA - lateral medullary/wallenberg's syndrome

AICA - lateral pontine syndrome