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10 Cards in this Set
- Front
- Back
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AA amyloidosis |
Chronic inflammatory disease eg RA, bronchiectasis, FMF, leprosy Hepatosplenomegaly Malabsorption CCF with low QRS voltage and exquisite sensitivity to digitalis Proteinuria Amyloid deposit on the skin Peripheral neuropathy Amyloid-induced synovitis Diagnose: abdominal fat biopsy or rectal biopsy (positive Congo red stain) |
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Hyperviscosity syndrome |
Bleeding + visual disturbance + neurological symptoms Waldenstroom macroglobulinemia Polycythemia rubra Vera Multiple myeloma Leukaemia |
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Hb electrophoresis |
Cannot detect alpha thalassemia (associated with hydrops fetalis) |
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Multiple myeloma |
When to treat: - paraprotein IgG >30 - any of C R A B (skeletal survey) Treatment: thalidomide + dexamethasone + bortezomib |
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Wiskott Aldrich syndrome |
X-linked g Reduced B cells and IgthrombocytopeniaEczema thrombocytopenia Eczema |
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Iron overload |
Grey skin Early heart failure Diabetes SE of desferrioxamine: high frequency deafness and retinopathy |
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Pentad of TTP |
Confusion Pyrexia Kidney disease Thrombocytopenia Microangiopathic haemolytic anaemia Plasma exchange CONTRAINDICATION: platelet transfusion |
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PNH |
Budd chiari syndrome Pancytopenia (platelets tend to agglutinate) Red urine in the morning
Flow cytometry CD55 and CD59 |
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Von Willebrand disease |
Desmopressin can be used to stimulate vWF release from endothelial cells |
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Anaphylaxis in blood transfusion |
IgA deficiency - therefore developed anti-IgA antibodies |
