Microbiology - Zoonotic Bacteria

Front 1

Zoonotic bacteria

Back 1

1. Borrelia burdorferi
2. Francisella tularensis
3. Yersinia pestis
4. Pasteurella multocida
5. Brucella spp.

Front 2

Borrelia burgdorferi: Disease states

Back 2

Lyme disease

Front 3

Brucella: Disease states

Back 3

Undulant fever/Brucellosis.
Temperature slowly rises during day, peaks in the evening, and slowly declines to normal by morning.
Accompanied by other systemic symptoms.

Front 4

Brucella: Transmission

Back 4

from animal contact (meat worker, farmer, veterinarian) or unpasteurized milk

Front 5

Gross mechanism of brucellosis

Back 5

1. Penetration of skin (but no buboes or primary skin ulcer), conjunctiva, lungs, GI tract
2. Lymphatic spread
3. Facultative intracellular growth in macrophages, and blood and organ invasion

Front 6

Francisella Tularensis: Disease states (list)

Back 6

Tularemia, either:
1. Pneumonic
2. Oculoglandular
3. Ulceroglandular
4. Typhoidal
(Don't POUT when you've got tularemia.)

Front 7

Describe Ulceroglandular tularemia

Back 7

a. Well-demarcated hole in the skin with a black base
b. Fever and systemic symptoms
c. Swollen/red/painful purulent lymph nodes -
Similar to plague, but with skin ulcer, and low mortality.

Front 8

Francisella tularensis: Transmission

Back 8

Most common: Handling of infected rabbits or from bites of ticks and deer flies - Hundred creatures in total all over US. Mnemonic: Francis the rabbit is playing in the TULips, with a deerfly on one ear and a tick on the other.

Front 9

Virulence of Francisella tularensis

Back 9

Very. (10 organisms cause disease.)

Front 10

Diagnosis of Francisella tularensis

Back 10

Clinical picture, PPD-like skin test, and titers of Francisella Ig

Front 11

Yersinia pestis: Transmission

Back 11

PESTS like rats harbor the disease and fleas are the vector, biting the skin of humans.
Found in campers, hunters, and hikers.
Mnemonic: A rat driving a fuel-injected (F1) VW bug (V and W antigens) fleeing (flea-ing) from a macrophage.

Front 12

Fraction 1 (F1) antigen

Back 12

Enables Yersinia pesitis to resist destruction after phagocytosis (facultative intracellular) - Mnemonic: A rat driving a fuel-injected (F1) VW bug (V and W antigens) fleeing (flea-ing) from a macrophage.

Front 13

V antigen

Back 13

Enables Yersinia pesitis to resist destruction after phagocytosis (facultative intracellular)
Mnemonic: A rat driving a fuel-injected (F1) VW bug (V and W antigens) fleeing (flea-ing) from a macrophage.

Front 14

W antigen

Back 14

Enables Yersinia pesitis to resist destruction after phagocytosis (facultative intracellular)
Mnemonic: A rat driving a fuel-injected (F1) VW bug (V and W antigens) fleeing (flea-ing) from a macrophage.

Front 15

Yersinia pestis: Presentation in humans

Back 15

1. Lymph node (usually inguinal [boubon is Greek for groin]) becomes inflamed (all four signs).
2. Fever, and headache.
3. Blackish discoloration under skin ("Black death")

Front 16

Disease states caused by Yersinia pestis

Back 16

Bubonic plague/pneumonic plague

Front 17

Pasteurella Multocida: Transmission

Back 17

Cat, dog, and animal bites. Also infects birds. Mnemonic: Cat and dog chasing a bird in a "Pasteur".

Front 18

T/F: All Zoonotic Gram negative bugs are facultative intracellular.

Back 18

False. Pasteurella is not.

Front 19

Pasteurella: Treatment

Back 19

Do not suture wound after dog or cat bite/scratch. (Best breeding ground for Pasteurella) Treat with penicillin or doxycycline.