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35 Cards in this Set
- Front
- Back
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All hepatitis viruses cause what?
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liver disease/jaundice
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infectious hepatitis?
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HAV
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serum hepatitis?
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HBV
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Hepatitis B is normally asymptomatic but what can happen following acute liver disease?
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chronic infection, resolution with immunity, or fulminant hepatitis
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What family does HBV belong to?
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hepadnavirus (B happenin)
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Why is it so important to vaccinate against Hepatitis B right away?
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infants have 90% chance of developing chronic hepatitis (vs 10% of adults)
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Nucleic acids of Hep B?
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dsdna with DNA polymerase!
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Which Hepatiditis increase risk of HCC?
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Hep B, C
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Flaviflav hepatitis? risk of chronicity?
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Hepatitis C; acute is subclinical but 80% become chronic
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Naked RNA hepatitis viruses?
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A and E
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High mortality in pregnant women?
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Hepatitis E
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Hepevirus hepatitis?
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Hepatitis E (enteric)
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What family is hepA?
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picornavirus (porno virus)
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Hepadnavirus mortality rate?
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1-2% (HBV)
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high mortality rate hepatitis virus?
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hepatitis D
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mode of transmission of HBV?
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sex, blood, perinatal (PERI)
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Infectious HBV particle?
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dane particle
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Major HBV particle in the blood?
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HBsAg
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What is HBcAg?
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nucleocapsid of the virion, encapsidates the genome
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Used as a marker for active HBV replication
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HBeAg
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What antigen is never in blood?
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HBcAg
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first hep B antigen to appear?
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HBcAg IgM - a sign of acute infection; note that the actual Ag never appears in the blood
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How is HBV replicated?
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genome 2nd strand is completed and ligated; mRNAs are transcribed from the repaired genome by HOST RNA pol II; the RNA is packaged into core, reverse transcribed, and not fully complete by the time core BUDS through ER
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Where is the HBs Ag envelope from?
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endoplasmic membrane
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What is thought to cause cancer after HBV infection?
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accidental HBV genome integration into host cell DNA
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Three liver enzymes released from hepatitis ddamage?
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ALT, AST, alkaline phosphatase
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Hep B liver damage due to?
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immune response
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Marker for current infection?
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HBcAg IgM
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What is the vaccine for HBV?
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HBsAg made in yeast; the first anti-cancer vaccine with two booster shots
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Treatment for Hep B
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Interferon (curative in 25%), Lamivudine, or Liver transplant
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What is the problem with liver transplants for HBV and using lamivudine?
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reinfection and viral resistance developing quickly.
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HDV genome is?
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small, circular, single stranded RNA that contains a ribozyme sequence.
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Why does HDV require coinfection?
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It needs a HBs Ag coat to be infectious
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What does the HDV nucleocapsid consist of?
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HDAg only!
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Most severe form of viral hepatitis?
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HDV
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