Microbiology - Flaviviruses And Togaviruses

Front 1

What are the arboviruses?

Back 1

Flaviviridae, Togaviridae, Reoviridae (arbo indicates mode of transmission, not family)

Front 2

Jungle cycle vs urban cycle?

Back 2

Jungle: insect-monkey-insect
Urban: insect-man-insect

Front 3

What are the positive RNAs

Back 3

Call Pico and Flo To Come Rightaway
Calicivirus, Picornavirus, Flavivirus, Togavirus, Coronavirus, Retrovirus

Front 4

What are the only naked RNA viruses?

Back 4

C Porn Repeatedly
Calicivirus
Picornavirus
Reovirus

Front 5

Which are the segmented RNA?

Back 5

ROBA:
Reovirus
Orthomyxa
Bunya
Arena

Front 6

Vector for Flaviviridae?

Back 6

Mosquito or tick

Front 7

Virion structure of Flaviviridae?

Back 7

+ssRNA, enveloped

Front 8

What diseases do Flaviviridae cause?

Back 8

West Nile, Yellow Fever, Dengue Fever, St. Louis Encephalitis, HCV!!

Front 9

Most cases of WNV presents how?

Back 9

inapparent except for mild feve and over in a week.
Serious cases result in encephalitis

Front 10

WNV Hosts?

Back 10

Birds

Front 11

Reservoir for SLE?

Back 11

Birds, but SLE virus is not a pathogen in birds or horses.

Front 12

Transmission of SLE?

Back 12

mosquito

Front 13

Encephalitis, aseptic meningitis, renal failure around Ohio and Missisippi River basins

Back 13

SLE

Front 14

Moquito bite in Tropical Africa and South America. What appears in my liver?

Back 14

councilman bodies

Front 15

Pathogenesis of Yellow fever?

Back 15

1-3 days incubation, then
first stage: N/V with hemorrhage and hypothermia
second: venous stasis, hemorrhage, kidney probs

Front 16

Theiler vaccine is what?

Back 16

live, attenuated, for Yellow fever virus

Front 17

Most common arthropod borne disease?

Back 17

Dengue virus (Daaang its common but without significant portality)

Front 18

Geographic distribution of Dengue virus?

Back 18

everywhere with both a jungle and urban cycle

Front 19

I get a biphasic fever with loe WBC and platelet count. What do I have and how many serotypes?

Back 19

dengue fever caused by one of four dengue viral serotypes

Front 20

What is the pathogenesis of dengue hemorrhagic fever?

Back 20

When a subsequent infection of the dengue virus of a different serotype is not neutralized by prior ABs and instead can infect macrophages via Fc and complement receptors.

Front 21

Hosts of yellow fever?

Back 21

Due to both jungle and urban cycles, the hosts for this virus are both monkey and man

Front 22

DHF occurs most often in who?

Back 22

children less than 12 yrs old

Front 23

diagnosis of flaviviridae?

Back 23

isolation from blood, not so much CF or HAI due to cross reacting Abs between flaviviridae

Front 24

Flaviviridae found in USSR?

Back 24

tick-borne encephalitis

Front 25

Flaviviridae found in asia?

Back 25

japanese encephalitis

Front 26

Togaviridae causes what diseases?

Back 26

the alphaviruses cause encephalitis; rubivirus causes german measles

Front 27

Pathogenesis of alphaviridae-mediated encephalitis?

Back 27

a 2-day systemic malaise then a potentially fatal encephalitic phase

Front 28

Which alphaviridae encephalitis is most severe?

Back 28

EEE is EEEK! 70% death
Wee is little (<10%

Front 29

Epidemiology of EEE?

Back 29

least common usually EEEE and south USA

Front 30

epidemiology of WEE?

Back 30

around 200 cases a year WEE is WEEst of the missippi

Front 31

most common togaviridae encephalitis?

Back 31

VEE gets thousands per year in south and central america (non us)

Front 32

Diagnosis of togaviridae encephalitidies?

Back 32

viral recovery in blood, brain, or csf; also sera to ID by antibody

Front 33

What Togavirus is not spread via arthropods?

Back 33

Rubivirus (Rubella virus)

Front 34

What is transplacental infection of Rubivirus dependent upon?

Back 34

if mother is in viremic phase and dependent of gestational age (determines transmission % and severity of disease)

Front 35

Clinical manifestations of babies with rubella?

Back 35

blueberry muffin babies (TTP)
salt and pepper (cataract retinopathy)
celery stalking (osteitis)

Front 36

Most common cause of congenital sensorineural deafness before vaccinations existed?

Back 36

congenital rubella

Front 37

Most common arboviral infection in US: virion family and structure?

Back 37

this is Orbivirus (mountain fever aka colorado tick fever); belongs to Reovirus which is dsRNA naked, segmented

Front 38

What does colorado tick fever present as?

Back 38

kinda like R. Rickettsia; biphasic fever and 10% have a rash

Front 39

Rotavirus genome?

Back 39

11 dsRNA!

Front 40

disease caused by rotavirus?

Back 40

Gastroenteritis that resolves in 2-7 days ; this is significant in infants and adult IC