Inorg Lec (10)

Front 1

it is essential to the elementary metabolic processes in the cell

Back 1

iron

Front 2

daily requirement of iron for male is ____, for female is ____, and for gestation is ____

Back 2

0.6mg

1.2 to 1.8mg

3 to 4mg

Front 3

The absorption of iron occurs in the ____ of the duodenum

Back 3

upper part

Front 4

The transport of iron in the intestinal mucosa is facilitated by ____, HCl fructose and other organic molecules which tend to iron in as soluble ____

Back 4

ascorbic acid

ferrous state

Front 5

it suggests that iron absorption follows various steps

Back 5

mucosal block hypothesis

Front 6

**1 Dietary irom is reduced to ____ form, which ____ into the intestinal mucosal cell where it is oxidized and combined with ____ to form stable ferritin

Back 6

ferrous

diffuses

apoferritin

Front 7

**2 As ____ crosses the cell and is released again to ____ for diffusion across the ____ cell membrane

Back 7

ferritin

ferrous iron

serosal

Front 8

**3 Eventually, it is re oxidized again to ____ and combined with the iron transport protein known as ____

Back 8

ferric ion

transferrin

Front 9

**4 In this form, it is transferred to the ____ for storage, or in the bone marrow for the use in the heme synthesis for ____ production

Back 9

liver

erythrocyte

Front 10

it is a hypothesis where it does not show th extent of absorption which is limited by ferritin

Back 10

mucosal block hypothesis

Front 11

Active Transport Mechanism of Iron:

The ferrous enters the ____ by diffusion where it combines with endogenous LMW ligands; or it is stored as ____. To cross the serosal membrane into the blood, a specific transport system is linked to ____ has been suggested

Back 11

mucosal cell

ferritin

ATP

Front 12

it suggests that endogenous ligands or chelating agents can bind either the ferrous or ferric form to form LMW ligands complexes capable of passively diffusing through the mucosal membrane from the instestine

Back 12

iron chelate hypothesis

Front 13

iron-containing proteins responsible for respiration and for carrying oxygen

Back 13

homoproteins

Front 14

a respiratory enzyme

Back 14

cytochrome C

Front 15

it is complexed in a porphyrin ring system which is in turn covalently bonded to the protein protion of the molecule which is shielded to prevent interaction of oxygen

Back 15

cytochrome C

Front 16

it stores and transports oxygen and it complexes with molecular oxygen

Back 16

hemoglobin or myoglobin

Front 17

iron storage proteins found in the liver, spleen and bone marrow

Back 17

ferritin and hemosiderin

Front 18

it is water insoluble and is considered by some to be a dehydrated ferritin

Back 18

hemosiderin

Front 19

it is the major iron transport protein of blood plasma whicb is glycoprotein

Back 19

transferrin aka siderophilin

Front 20

transferrin is aka

Back 20

siderophilin

Front 21

deficiency of iron

Back 21

anemia

Front 22

it is widely distributed in the tissues and abundant in the liver and it is seen in the plasma as bound with alpha globulin and in RBC

Back 22

copper

Front 23

daily requirement of copper

Back 23

2-5mg/kg/day

Front 24

Copper could facilitate ____ absorption, it could be stimulatory to the enzymes in the ____ or ____ synthesis

Back 24

iron

heme

globin

Front 25

Copper is also important in oxidative ____, it is associated with the formation of ____; Copper is a component of ____

Back 25

phosphorylation

aerobic elastin

tyrosinase

Front 26

____ is an enzyme responsible for the conversion of tyrosine to the black pigment called ____

Back 26

tyrosinase

melanin

Front 27

Deficieny of copper for infants can lead to

Back 27

neutropenia

Front 28

Pt have increased copper levels in the liver, brain, kidney and cornea

Back 28

Wilson's disease

Front 29

antidote for phosphorous poisoning

Back 29

cupric sulfate

Front 30

it is widely dsitributed in the body and is an essential dietary mineral associated with certain metalloenzymes

Back 30

zinc