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6 Cards in this Set

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Topical Hyperosmotic Agents

Sodium chloride - most commonly used



Glycerin (Glycerol) - used clinically



Glucose



Isosorbide



Mannitol

Topical Hyperosmotic Agents MOA

Dehydrate edematous cornea



Increase tonicity of tear film by being hyperosmolar to the ocular tissue fluid



Increase rate of movement of fluid from cornea; with application water is drawn from cornea to more highly osmotic tear film and eliminated through usual tear flow mechanisms



Patients with minimal to moderate edema have improved comfort and vision with hyperosmotics

NaCL - Sodium Chloride

Muri-128



Concentrations 2 and 5%



Soln.

Glycerin

Ophthalgan (topical); Osmoglyn (oral)



Compounded



Soln

Glucose

Compounded



Ung

Mannitol


1. Osmitrol (IV)