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25 Cards in this Set

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Glysocaminoglycans (GAG)
polysaccharides of disaccharides. Includes dermatan sulfate, chondroitin sulfate, keratin sulfate, and heparan sulfate.
Dermatan Sulfate
GAG. Found in dermis, tendons, ligaments, and fibrous cartilage.
Chondroitin Sulfate
GAG. Found in hyaline cartilage and elastic cartilage
Keratin Sulfate
Found in cornea. GAG
Heparan Sulfate
Associated with reticular fibers and basal laminae.
Proteoglycans
Intensely hydrated tructures that act as selective physical barriers.
Hurler's Syndrome
Abnormal accumulation of extracellular proteoglycans and secretion of dermatan sulfate and heparan sulfate into urine. Leads to bone and cartilage abnormalities and mental retardation.
Type I Collagen
Most abundant. Widespread distribution. Forms fibers and bundles. Found in bone, tendons, skin, dermis, and loose connective tissue.
Type II Collagen
Forms fibrils only. Found in hyaline and elastic cartilage. Cartilage matrix in adults.
Type III Collagen
First collagen synthesized by body. Forms reticular fibers during wound healing.
Type IV Collagen
Does not form fibers. Found in basal laminae
Type V Collagen
Does not form fibrils. Found in fetal amnion, chorion, muscles, and tendons.
Reticular Fibers
Synthesized by fibroblasts and stain with silver. Composed of primarily type III collagen. Form network for hematopoietic organs.
Elastic Fibers
Show extreme elasticity. Synthesized by fibroblasts.
Ehlers-Danlos Syndrome
Inherited disorders of defects in the synthesis and structure of collagen. Presents as laxity of tendons and ligaments, bruising, and fragile tissues.
Marfan Syndrome
Genetic disorder in which connective tissue is excessively elastic. Cause by mutation in fibrillin gene. Symptoms include aortic aneurysms, scoliosis, and ocular defects.
Mesenchymal Cells
Progenitor cells that give rise to connective tissue, including fibroblasts.
Fibroblasts
Large, stellate cells that stain pale. Large ovoid nucleus. 1-4 nuclei. Synthesis of fibers, intercellular ground substance, and tissue repair.
Scleroderma
Genetic disorder in which fibroblasts undergo uncontrolled growth and collagen synthesis. Causes thick skin, impaired blood flow, and difficulty swallowin
Macrophages/Histiocytes
Monocytes differentiate into macrophages after migrating into connective tissue. Secrete several factors.
Mast Cell Disorder
Hay fever. Allergic rhinitis marked by itching and lacrimation, sneezing, and irritation of nasal mucosa.
White Adipose Cells
Extremely large, signet ring. Flat nuclei. Single lipid droplet. Originate from lipoblasts.
Brown Adipose Cells
Contain multiple lipid droplets, many mitochondria (hence color). Eccentric nucleus.
Loose (areolar) connective tissue
Flexible, vascularized. Contains fibroblasts and macrophages. Has collagen, elastic, and reticular fibers. Found in mesentery, omentum, dermis, hypodermis, and glands.
Dense Irregular Connective Tissue
Sparse ground substance and fewcells. Numerous collagen fibers irregularly arranged. Less flexible but resistant to stress. In dermis and organ capsules. Non-lactacting breast.