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5 Cards in this Set

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  • Back

Where does Hematopoietic Stem Cell differentiation occur throughout a life cycle?

Begins in Yolk sac initially -> migrates to Liver prenatally -> migrates to entire skeleton Red Marrow postnatally -> migrates to axial skeleton in adults.

Where does postnatal Hematopoiesis occur?

In Trabecular Marrow of bonese, which have medullas within that support differentiation, proliferation, maturation of progenitors.

What are key features of Hematopoietic Stem Cells?

Pluripotent, Self-renewing.

What triggers differentiation of HPCs?

Growth factors and CYTOKINES released during immune responses.

What does Tri-Lineage refer to?

Refer to hematopoiesis of Myeloid, Erythroid, and Megakaryocyte differentiations.