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15 Cards in this Set
- Front
- Back
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Linoleic acid
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18:2 to arachidonic acid omega 6
(9, 12) |
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linolenic acid
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18:3 to DHA omega 3
(9,12,15) |
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characteristics of essential FA's
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humans can't synth dbl bond at omega 6 or less
most human FA's unconjugated essentials penetrate skin |
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process of FA series
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desaturase (NADPH)
elongase (2NADPH) -acetate donor is methylmalonyl CoA (ACoA in mito rxns) Desaturase again |
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FA series'
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omega 6:
-linoleic to DGLA to arachadonic omega 3: -linolenic to EHA to DHA omega 9: -oleic to meads acid |
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triene/tetraene ratio
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meads/aa
high means defect in FA's |
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regulation of FA series
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mass action
oleic is not essential will predominate if missing essentials |
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conjugated FA's
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CLA's
desaturase is only 2 carbons vaccenic acid to rumenic anticarcinogenic & antiox |
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rumenic acid
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cis 9 trans 11
conjugated FA made in humans from veccinic (sp?) antiox, anticancer |
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functions of essential FA products
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inflammation
CNS esp 1st 3 mo of life retina very fluid- keep membranes fluid |
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characteristics of transfats
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increase LDL, total, TG
decrease HDL increase CVD decrease growth rate in children advers affect CRP, TNF, E select, IL 6 & CAM's disrupt PG balance change membrane fluidity |
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DHA
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22:6
(4, 7, 10, 13, 16, 19) docosahexanoic |
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EPA
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20:5
(4,8,11,14,17) Eicosapentaenoic acid |
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DGLA
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intermed to arachadonic acid
20:3 Dihomo-gamma-linolenic acid |
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arachadonic acid
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20:4
(5, 8, 11, 14) |
