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17 Cards in this Set
- Front
- Back
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What controls motility and secretory functions of intestines?
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enteric nervous system
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first line NTs in the gut?
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dopamine, serotonin
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MoA of metoclopramide
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5-HT4-receptor agonist (enteric)
D2-receptor antagonist (enteric nerves, chemo-receptor trigger zone) |
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Side effects of metoclopramide
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extrapyramidal effects (lip smacking, ticks)
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MoA of cisapride
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5-HT4-receptor agonist
inc LES tone |
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Side effects of cisapride
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prolongs QT interval
cause arrhythmias when combined w/ P450 |
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MoA of macrolide antibiotics
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motilin receptor agonist
augments gastric and SB motility |
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Side effects of macrolide antibiotics
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diarrhea
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MoA of ondansetron
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blocks 5-HT3 at multiple sites (SB, vagal efferents, CTZ, Nucleus tractus solitarius) to suppress vomiting
effective for chemo-induced N/V |
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Dopamine-receptor antagonist MoA
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inhibit dopaminergic stimulation of CTZ
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Uses of cannabinoid-receptor agonist
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stim appetite, suppress vomiting
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Antihistamine MoA
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blocks H1 receptors
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Side effects of antihistamine
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drowsiness, dry mouth, blurred vision
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MoA of loperamide
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opioid, stim enteric, but not central, mu-opiod receptors
inc orocecal transit time & anal sphincter tone |
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Side effects of using loperamide
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can cause toxic megacolon, especially in C diff
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MoA of diphenoxylate
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opiod, stimulates enteric mu-opioid receptors
can penetrate CNS and stim central receptors |
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Primary use of cholestyramine
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cholerrheic diarrhea and adjunctive use in C diff
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