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26 Cards in this Set
- Front
- Back
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Generic |
A name that specifies a particular chemical but not a particular brand |
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Provigil (modafinil) |
A medication used to treat narcolepsy, shift work sleep disorder, and daytime sleepiness associated with sleep apnea |
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Nuvigil (armodafinil) |
A longer-lasting version of modafinil, approved to treat the same conditions |
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Placebo |
An inactive drug |
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Double-blind procedure |
Experiment in which neither the doctor nor the patient knows which drug is being used |
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Dose-response curve |
A graph comparing the size of response to the amount of drug |
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Ataxia |
Uncoordinated walking |
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Comatose |
Unconscious and unable to be aroused |
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ED50 |
Effective dose for half of the animals tested |
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LD50 |
Lethal dose for half of the animals tested |
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Therapeutic Index (TI) |
Ratio of LD50 to ED50 |
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Safety margin |
Dosage difference between an acceptable level of effectiveness and the lowest toxic dose |
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Side effects |
Unintended effects that accompany therapeutic effects |
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Potency |
Measured by the amount of drug required to produce an effect |
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Time Course |
Timing of the onset, duration, and termination of a drug's effect |
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Cumulative Effects |
Effects of giving multiple doses of the same drug |
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Lipid Solubility |
Tendency of a chemical to dissolve in fat, as opposed to in water |
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Intravenous (IV) |
Injection directly into a vein |
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Subcutaneous |
Injection under teh skin |
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Intramuscular |
Injection into a muscle |
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Metabolite |
Product of enzyme action on a drug |
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Active metabolite |
Metabolites that have drug actions of their own |
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Prodrugs |
Drugs that are inactive until acted on by enzymes in the body |
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Drug disposition tolerance |
Tolerance caused by more rapid elimination of the drug |
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Behavioral tolerance |
Tolerance caused by learned adaptation to the drug |
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Pharmacodynamic tolerance |
Tolerance caused by altered nervous system sensitivity |
