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22 Cards in this Set
- Front
- Back
Embryonic Origin of Connective Tissue |
Mesoderm |
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5 Functions of Connective Tissue |
Structural Support Medium for nutrient/waste exchange Defense/Protection Body Energy Storage Repair after injury |
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Preprocollagen compostition |
Glycine, Proline, Hydroxyproline, hydroxylysine |
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Collagen Formation |
3 preprocollagen molecules align and from a helical procollagen molecule At secretion procollagen peptidases remove terminal protein making tropocollagen Tropocollagen polymerizes to form fibrils Fibrils polymerize to form collagen fibers |
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Reticular fibers are covered by |
Glycoprotein coat |
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Do Elastic Fibers have hydroxylysine |
No |
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Desmosine |
For lysine molecules of different elastin chains covalently bond. Imparts elasticity |
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Fibrillin |
Forms microfibrils surrounding elastin |
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Formation of Elastic Fibers |
Fibrillin microfibrils laid down Elastin deposited on the microfibrils |
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Enzyme that breaks down elastin |
Pancreatic elastase |
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Ground substance composition |
Water Glycosaminoglycans (GAGs) Proteoglycans Multiadhesive glycoproteins |
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Function of Ground substance |
Lubricates and acts as a barrier to invaders |
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How do GAGs resist compression |
Negative charge attracts water and repels each other making things slippery |
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Aggrecan |
Proteoglycan responsible for the gel state of the EMC and acts as diffusion barrier |
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Glycoprotein function |
Allow cell and other things to attach to ECM. Cells attach through integrins Mediate interactions between cells |
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Examples of Glycoproteins (2) |
Laminin and Fibronectin |
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Ehlers-Danlos Syndrome |
Stops Hydroxylation of Lysine and inhibits Proteases cleaving ends Leads to increased Skin elasticity and potential eyeball rupture |
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Dermatosparaxis |
Inhibits proteases the cleave ends Thin skin |
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Hereditary Equine Regional Derma Asthenia (HERDA) |
Linked to protein mutations in procollagen chaperoning Specific for dermal layer |
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Marfan Syndrome |
Reduced amount of fibrillin and therefore elastic fibers |
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Cutaneous Mucinosis |
Makes more GAGs and hyalonic acid Only in dermis Increases hyaluronian synthesis enzyme |
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3 characteristics of a Tendon |
DRCT Boxcar effect/arrangement Basophilic streaming |