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41 Cards in this Set

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What are the boundaries of ct?
basal lamina of epithelia, external lamina of nerve supporting / muscle cells
All of the following are functions of connective tissue except:

a) Provides form and structure
b) Site of molecular exchange
c) Provide an electrochemical gradient and used in communication
d) Role in protection and thermoregulation
c
In connective tisse, the extracellular matrix is composed of:

a) ground substance + fibres
b) cytoplasm + ground substance
c) collagen
d) eosinophils
a
Name the two types of CT
loose and dense
also regular and irregular
Which statement is false regarding loose connective tissue?

a) characterized by sparse, thin collagen fibers
b) abundant ground substance
c) site of the first immune response
d) primarily located
beneath endothelium
d
Actually Primarily located
beneath epithelia
covering and lining body
surface
Which is false regarding dense irregular connective tissue?

a) very few cells
b) abundant ground substance
c) provides significant strength
d) mostly fibroblasts
b
very little ground substance
Which statement is false regarding dense, regular connective tissue?

a) form the main functional components of tendons and ligaments
b) densely packed, ordered fibres and cells
c) sparse, thin collagen fibers
d) none of the above
c
T or F: collagen fibres, reticular fibres and elastic fibers are all produced by fibroblasts.
T
Collagen fibres are made up of _____
fibrils
T or F: collagen does not break down with age
F
The structure of collagen is ____________, and requires proline, glycine
and hydroxyproline.

a) helical
b) double helix
c) triple helix
d) coiled coil
e) none of the above
c
90% of the body's collagen is
Type I collagen
Type II collagen is known as
cartilage
Type III collagen is known as
reticular fibres
Type IV collagen is known as
basement membrane?
Reticular fibrils stain ________ with silver stain.

a) red
b) black
c) blue
d) orange
b
reticular fibres are usually indicative of
tissue maturity
reticular fibres are important in wound healing. why>?
they provide strength to the newly synthesized ecm
elastic fibres are produced
Produced by fibroblasts &
vascular smooth muscle
cells
What provides elastic fibers their elasticity?
randomly coiled backbone and the presence of Gly (makes it easy to coil) and lack of hydroxyproline
Where can you find elastic fibres?
ligaments of spine and neck, larynx, arteries
All CT is derived from?
mesenchyme
(except neuroglia)
Adult CT:

a) is irregular, branching, with anastomosing cells lying in the ground substance
b) results from differentiation in the intercellular substance and cells
c) none of the above
d) both a and b
b
What is the ground substance comprised of?
= Proteoglycans,
Multiadhesive glycoproteins and
glycosaminoglycan
All of the following are functions of the ECM except:

a) anchors cells to each other
b) biochemical barrier
c) provides tensile strength
d) regulates metabolic function
a
Glycosaminoglycans
(GAGs) are:
Responsible for the physical
properties of GS
Proteoglycans are
GAGs covalently linked to core proteins
What is the function of Multiadhesive
glycoproteins
stabilized ECM and links it to surfaces of cells
GAGs and PGs are examples of

a) heteropolysaccarides
b) multiadhesive glycoproteins
c) extracellular matrices
d) none of the above
a
Hyaluronan is a type of
GAG
Why is hyaluronan unique?
no post-translational modification (unlike other GAGS)
does not contain sulfates and does not form proteoglycans but may form proteoglycan aggregates
Types of cells in connective tissue: (2)
resident
wandering
what cells are classified as resident cells?
fibroblast
macrophage
adipocyte
mast cell
stem cell
what cells are classified as wandering?
lymphocyte
plasma cell
neutrophil
basophil
eosinophil
monocyte
T or F: fibroblasts and myofibroblasts are easily distinguishable
F
under H&E can't really distinguish the two
Distinguishing characteristic of macrophages?
kidney shaped nucleus
There are many _______ in the cytoplasm of macrophages.

a) lysosomes
b) mitochondria
c) neither
a
Which type of cells develop in bone marrow? Where do they differentiate?
mast cells and basophils develop in bone marrow and differentiate in CT
Mast cells and basophils:

a) are found in the CNS
b) are found in the circulatory system
c) develop and differentiate in CT
d) are mediators of the inflammatory response
e) none of the above
d
adipocytes are arranged in _________ of fat cells and are derived from ______________ CT cells.

a) groups; adult
b) clusters; mesenchyme
c) groups; embryonic
d) clusters; embryonic
c
Where is the nucleus in an adipocyte?
pushed to the periphery along with the cytoplasm