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9 Cards in this Set
- Front
- Back
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What are the first-line drugs in the treatment of TB?
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Isoniazid, rifampin , pyrazinamide.
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What are the 2 clinical manifestation groups of TB?
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1. Active TB - dyspnea, fever, productive cough, and night sweats for 2 months, with upper lobe consolidation and acid-fast bacilli.
2. Patients with a reactive PPD skin test, representing a latent infection. |
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Patients with latent TB infection are usually treated how?
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6-12 months INH prophylactic therapy?
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What are some important features of anti-TB antibxs?
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1. All cause hepatotoxicity
2. All are absorbed orally 3. All penetrate into most tissues (need to reach the center of caseous granulomas) |
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Besides hepatotoxicity, what's another adverse effect of INH?
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Decreased B6 levels and potentially pellagra (neuropathy, rash, and anemia)
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Which drug causes urine, feces, saliva, sweat, and tears to be colored a bright red-orange color?
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Rifampin
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What's the leprosy drug you should know?
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Dapsone
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What are the leprosy reactions?
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Reactions developed by 50% of leprosy patients in response to treatment.
1. Type 1 - occur only in borderline patients, with a delayed hypersensitivity reaction to the dead bacilli. 2. Type 2 - erythema nodosum leprosum |
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What is the treatment of choice for leprosy patients who experience a Type 2 leprosy reaction to dapsone?
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Thalidomide
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