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9 Cards in this Set

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What are the first-line drugs in the treatment of TB?
Isoniazid, rifampin , pyrazinamide.
What are the 2 clinical manifestation groups of TB?
1. Active TB - dyspnea, fever, productive cough, and night sweats for 2 months, with upper lobe consolidation and acid-fast bacilli.
2. Patients with a reactive PPD skin test, representing a latent infection.
Patients with latent TB infection are usually treated how?
6-12 months INH prophylactic therapy?
What are some important features of anti-TB antibxs?
1. All cause hepatotoxicity
2. All are absorbed orally
3. All penetrate into most tissues (need to reach the center of caseous granulomas)
Besides hepatotoxicity, what's another adverse effect of INH?
Decreased B6 levels and potentially pellagra (neuropathy, rash, and anemia)
Which drug causes urine, feces, saliva, sweat, and tears to be colored a bright red-orange color?
Rifampin
What's the leprosy drug you should know?
Dapsone
What are the leprosy reactions?
Reactions developed by 50% of leprosy patients in response to treatment.
1. Type 1 - occur only in borderline patients, with a delayed hypersensitivity reaction to the dead bacilli.
2. Type 2 - erythema nodosum leprosum
What is the treatment of choice for leprosy patients who experience a Type 2 leprosy reaction to dapsone?
Thalidomide