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6 Cards in this Set

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What are the 2 gram-positive rods that don’t form spores?
Corynebacterium and listeria
Describe the clinical manifestations of a corynebacterium diptheriae infection?
Colonizes the pharynx, producing a grayish pseudomembrane. From this site, bacteria release exotoxin into the bloodstream, which specifically damages heart and neural cells by interfering with protein synthesis.
Culture requirements for corynebacterium diptheriae?
Potassium tellurite agar and Loeffler’s coagulated blood serum media
Treatment of diphtheria before culture results?
Antitoxin, penicillin or erythromycin, DPT vaccine
Listeria exhibits a tropism for…? Which groups are at risk? Why?
Nervous tissue  meningitis. Neonates and immunosuppressed patients are at risk. They are unable to activate their phagocytic cells (which have swalled the facultative intracellular Listeria) due to inadequate cell-mediated immunity.
When meningitis develops in a patient who is at high risk for Listeria, what antibiotics do we add empirically?
Ampicillin or trimethoprim-sulfamethoxazole