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18 Cards in this Set
- Front
- Back
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what side of the antibody do the antigens bind
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near N terminus
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what happens if antibodies are not very specific
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autoimmune disease
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what are the major classes of antibodies
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M G D A E
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what is the difference between polyclonal and monoclonal
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poly is collection of monos that can bind to several different epitopes of the same antigen (however, only one antibody per epitope)
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describe heavy and light domains
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heavy are made up of Vh Ch1 Ch2 Ch3
Light are made up of Vl and Cl |
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What is the different between variable and constant domains
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hypervariable loops
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where is the antigen binding site exactly
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hypervariable loo0ps
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what is the undrelying high specificity due to of antibodies
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H bonds and ion interactions
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what is a collagen fiber made up of
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array of tropocollagen molecules arranged in quarter staggered array
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what makes up the primary sequence of tropocollagen
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glycine every third aa
proline 20% hydroxyproline hydroxylysine |
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why is vit C important
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for hydroxylation of prolines and lysines which allows the protein to be soluble in the ctyoplasm
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what type of reaction is involved in hydroxlyation
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alpha ketoglutarate
mono oxygenases iron vit c |
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what holds together the C terminals of procollagen
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sulfide bonds of cys
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what happens to procollagen once it's outside the cell
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proteolytic enzymes
lysyl oxidase leads to intramolecular crosslinks which increases stability of collagen fibers |
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what happens in ehler danlos syndrome
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lysyl oxidase so bad hydroxylation
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when might you need to break down collagen
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post partum
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when could we take advantage of monoclonal antibodies
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to treat rheumatoid arthritis
Rituxan and anticancer drugs |
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what is lathyrcism
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suicide inhibitor of lysyl oxidase
caused by sweet pea |
