Antibiotics

Front 1

Sulfa Drugs

Back 1

Block synthesis of folic acid, thus nucleic acids

Front 2

Isonazid

Back 2

Nictoamide analog

Only effects mycobacterium

Effects mycologic synthesis (part of cell wall)

TB

Front 3

Quinolones

Back 3

interferes with DNA Gyrase

Prevents supercoiling

Floroquinolones- have added floro group

Treat UTI's

agricultural use

Front 4

Ciproflaxin

Back 4

(Quinolone)

Anthrax

Front 5

Moxiflavocan

Back 5

(Quinolone)

TB

Front 6

Nucleic acid analogs

Back 6

Prevent Replication, Transcription, Translation

Front 7

Acyclovir, Ganoclovir

Back 7

(Nucleic acid analog)

Herpes

Front 8

B-Lactam

Back 8

Cell wall inhibitor

Binds to inactive transpeptidase

Prevents cross bridge formation

Front 9

Penicillin

Back 9

(B-Lactam)

Natural types G and V

Front 10

Ampicillin

Back 10

Resistant to B-Lactamases

Front 11

Methocillin

Back 11

(Penicillin) MRSA is Resistant

Front 12

Augmentin

Back 12

Amoxicillin + Clavolanic acid

Front 13

Cephalosporins

Back 13

B-lactam ring and Dihydrodiol ring

More resistant to B-lactamase

4 Generations

1. Just G+

2. G-

3. Peseudomonas

4. Oral

Front 14

Ceftriaxone

Back 14

(Cephalosporin)

gonorrhea

Front 15

Carbapenems

Back 15

Synthetic B-Lactam

Front 16

Doripenem

Back 16

(Carbapenem)

Pseudomonas Aerogonia

Front 17

Bacatracin

Back 17

(Cell Wall inhibitor)

Topical Antibiotic

Streptococcus, and Staphylococcus

Front 18

Vanocymicin

Back 18

(Cell Wall inhibitor)

Glycopeptide from amalcytase

Front 19

Aminoglycosides

Back 19

amino sugars with glycidic linkages

Kanamyosin, Centramycin, neomycin

Change shape of 30S subunit cause mRNA misreading

Harmful to Host

Front 20

Macrolides

Back 20

Large lactose rings connected to sugars

Binds to 50S subunit, prevents movement of mRNA

Erythromycin, Z-Pak,

Front 21

Tetracyclines

Back 21

4 rings, lots of modification possible

From Streptomyces

Interfere with tRNA attachment

Front 22

Chloramphnicol

Back 22

Binds to 50S subunit inhibits peptide bond formation

Supressed bone marrow formation

Front 23

Oxazolidinones

Back 23

Synthetic

Binds to 50S prevents 30S from attaching

Effective against MRSA

Front 24

Daptomycin

Back 24

(Plasma Membrane Injury)

Puts pores in membrane, lyses cell

Front 25

Polymyxin b lipopeptide

Back 25

(Plasma Membrane Injury)

Pseudomonas

With Bacatracin makes neosporin

Front 26

platensimycin

Back 26

Fatty Acid Inhibition

MRSA

New Class of Drug

Unique mode of action