Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
Resistance
mechanisms |
4 biochemical mechanisms
production of enzymes which inactivate the antibiotics alteration of the target of the antibiotic metabolic bypass preventing access of the antibiotics to its site of action |
|
|
Resistance
Types |
Acquired resistance
Inherent resistance |
|
|
Choice of Antibiotics
|
infective organism (esp. HAI)
antimicrobial susceptibility host factor |
|
|
Lab testing: most helpful in urgent situation...
|
Gram stain
Gram +ve: blue Gram -ve: pink |
|
|
Types of penicillin
|
Benzylpenicillin
b-lactamase resistant forms Broad-spectrum penicillins Extended spectrum penicillins Reversed-spectrum penicillins |
|
|
Benzylpenicillin
|
Gram +ve
not b-lactamase resistant |
|
|
b-lactamase resistant forms
|
Flucloxacillin
purely gram +ve only |
|
|
Broad-spectrum penicillins
|
Gram +ve and gram -ve
|
|
|
Extended spectrum penicillins
|
Pseudomonads
|
|
|
Reversed-spectrum penicillins
|
Aztreonam
Gram -ve |
|
|
Penicillins
|
cidal
beta lactams, bind to penicillin binding protein and inhibit transpeptidation target: narrow spectrum gram positive Resistance: destroyed by beta lactamase hydrolyzed in stomach side fx: allergic reaction, seizures (high iv doses) |
