Methicillin-resistant Staphylococcus aureus (MRSA), a dangerous derivative of Staphylococcus aureus bacterium infecting unsuspected victims and continue to …show more content…
These strains possess Staphylococcal Chromosomes Cassettes mec (SCCmec), which is a mobile genetic element carrying diverse beta-lactam resistance genes encoded by the mecA gene (Teruyo, 2009). The existence of MRSA is the results of the survival, acquisition, and insertion of the SCCmec into the chromosome of similar bacterial strains. The SCCmec are highly diverse in their genetic organization allowing MRSA to be classified and defined by the combination of SCCmec type and the chromosomal background in which SCCmec resides (Teruyo, 2009). The mec element SCCmec has been identified in multiple Methicillin-sensitive Staphylococcus aureus (MSSA) genetic backgrounds through MSSA DNA fingerprinting in combination of genetic structure of the particular SCCmec, creating an evolutionary profile (Hiramatsu, 2001; Hiramatsu, 1995; Fitzgerald, 2001; Enright, 2002; Oliveira, 2001). Studies indicated that epidemic MRSA were the result of successful transfer of the mec gene into an ecologically fit and transmission-efficient MSSA clones (Crisostomo, 2001; Enright, 2002).
Cystic fibrosis (CF) is a lifelong, hereditary disease common in the populations of Caucasians of Northern European descents. According to the American Lung Association, there is approximately 30,000 Americans with cystic fibrosis and more than 10 million Americans who are symptomless carriers of the recessive cystic fibrosis gene. As a