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64 Cards in this Set

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Metyrosine

Inhibits tyrosine hydroxylase to prevent L-DOPA formation

Reserpine

Inhibits vesicular storage of Dopamine

DRUGS THAT STIMULATE EXOCYTOSIS

Tyramine


Ephedrine


Amphetamine


AT II


Alpha-latrotoxin

DRUGS THAT INHIBIT EXOCYTOSIS

Guanethidine


Guanadrel


Bretylium

REUPTAKE INHIBITORS

Tricyclic antidepressants


Cocaine


Reboxetine

Product of norepinephrine and epinephrine metabolism

3-methoxy-4-hydroxymandelic acid or


vannilylmandelic acid

Product of metabolism of Dopamine

Homovanilic acid

1st line cardiac stimulant


1st line agent for anaphylaxis and anaphylactic shock




can be used as a vasoconstrictor (+ lidocaine)

Epinephrine or Adrenaline

A pivalic acid ester of epinephrine used to manage glaucoma

DIPIVEFRIN

1st line agent for septic shock

Norepinephrine/Noradrenaline/Levarterenol

Used to manage acute heart failure complicated by oliguria or anuria


Management of septic shock and cardiogenic shock

Dopamine

Toxic effects due to alpha 1 overstimulation

Vasoconstriction = digital necrosis

Toxic effects of beta 1 overstimulation

Ventricular tachyarrhythmias

A non selective beta agonist used as an alternative during shock states and for management of AHF

Isoproterenol aka. Isoprenaline

A beta 1 selective agonist used as a FIRST LINE agent for cardiogenic shock

Dobutamine

Used for pharmacological stress test to determine the cardiac function

DOBUTAMINE + DIPYRIDAMOLE

The only beta 2 selective agonist administered subcutaneously

TERBUTALINE

Off label use of terbutaline

TOCOLYTIC (mgt of preterm labor)

Toxic effects of beta 2 agonists

HYPOkalemia


Tremors

Local toxic effect of alpha 1 selective agonist administered intranasally

Rhinitis medicamentosa or rebound congestion

Alpha 2 selective agonist used for mgt of glaucoma

Apraclonidine and Brimonidine

Alpha 2 selective agonist used as an alternative for management of HTN (rapid acting) and ADHD

Clonidine

2 phases of effect of CLONIDINE

Initial : vasoconstriction (transient)


Final: lowers blood pressure (lasting)

Produces POSITIVE coombs test

Methyldopa

Dopamine 1 selective agonist used as an alternative for hypertensive crisis

Fenoldopam

1st line management of ADHD

Methylphenidate




alt: Amphetamine

Centrally acting symphatomimetics used as an ANOREXIANTS

Phentermine


Phenmetrazine


Phenylpropanolamine

Centrally acting sympathomimetics used in the management of Narcolepsy

Phentermine


Amphetamine

Used in the management of pheochromocytoma (excessive amounts of epinephrine)

Alpha blockers (alpha 2 blockers)


Beta blockers

Used in the management of Raynauds syndrome

Alpha blockers (alpha 2)


CCB's (dipine)

Used in the mgt of HTN and urinary retention in BPH patients but has a toxic effect called FIRST DOSE PHENOMENON

Alpha 1 blockers

An alpha blocker used in the management of erectile dysfunction

Phentolamine

An alpha blocker used in the management of Carcinoid syndrome (90% production of serotonin)

Phenoxybenzamine

Non selective beta blockers are contraindicated in?

Patients with bronchial asthma

NADOLOL


SOTALOL


TIMOLOL


PROPRANOLO

Beta blockers that are not associated with rebound hypertensions (low risk)

BETA BLOCKERS WITH intrinsic sympathomimetic activity (ISA) = beta 1 antagonist and beta 2 agonist

Beta blockers with membrane stabilizing action that possess local anesthetic effect, not to be instilled in the eye

Pindolol


Propranolol


Acebutolol


Labetalol


Metoprolol



PinPALM

MOST CARDIOSELECTIVE BETA BLOCKER

Nebivolol

Beta blockers used in the management of stable heart failure

Bisoprolol


Metoprolol succinate


Carvedilol


Nebivolol



Biso Met Carve and Nebi

Beta blockers used in the management of glaucoma

Timolol and Betaxolol

A beta blocker used in the management of sympathetic symptoms of hyperthyroidism, prophylaxis of acute migraine headache and management of stage fright

Propranolol

A toxic effect of beta blockers that is to be considered especially if the patients has diabetes

It masks hypoglycemic symptoms

Inhibits active uptake of choline

Hemicholinium

Inhibits vesicular storage of Acetylcholine

Vesamicol

Stimulator of exocytosis of Acetylcholine

Alpha latrotoxin

Inhibitor of exocytosis of Acetylcholine

Botulinum toxin

Parasympathomimetic used in the management of Alzheimers disease

CNS ACTING anticholinesterase


Tacrine


Donepezil


Galantamine


Rivastigmine

Best antidote in the treatment of anticholinergic poisoning (for peripheral signs and symptoms only)

Neostigmine

Treatment of paralysis due NMB toxicity

Neostigmine (intermediate acting, direct acting parasympathetic)


and Endrophonium (short acting, direct acting parasympathetic)

Curare derivatives, non depolarizing

Management of non obstructive ileus administered subcutaneously

Physostigmine (intermediate indirect acting parasympathetic)


Pilocarpine (alkaloid, muscarinic selective direct acting parasympathetic)

Parasympathomimetic used in the management of smoking cessation

Nicotine


Lobeline


Varenicline



NICOTINIC SELECTIVE ALKALOIDS, DIRECT ACTING

Parasympathomimetic used in the management of urinary retention

Betanechol (urecholine)

Used in the pulmonary challenge test for provocative test for bronchial hyperactivity

Metacholine

Antimuscarinic used in the management of motion sickness

Scopolamine

TWILIGHT SLEEP

Scopolamine + Morphine

Antimuscarinics used in the management of EPS and parkinsonism

Trihexyphenidyl, Benztropine, Diphenhydramine

M1 blocker used in the management of hyperacidity

Pirenzepine


Telenzepine

M3 antagonist used in the management of Hypermotility disorder and Urinary incontinence

Methscopolamine


Glycopyrrolate


Hyoscine


Dicycloverine


Oxybutinine


Scopolamine

Used as a preanesthetic agent to relax skeletal muscle prior to surgery and management of spastic disorder

Nm blockers

This drug acts by irreversibly activating Nm receptor, and it has two phase of effect


I: skeletal muscle contraction


II: relaxation or paralysis

Depolarizing Nm blocker/Succinylcholine

Causes malignant hyperthermia

Succinylcholine

acts by blocking Nm receptors causing immediate paralysis

Nondepolarizing Neuromuscular blocker/Reversible Neuromuscular

Used to treat malignant hyperthermia

Dantrolene

Type 1 NONDEPOLARIZING NM

ISOQUINOLINE (-curium)


Atracurium


Tubocurarine

Type 2 NONDEPOLARIZING NM

STEROIDAL (-curonium)


Pancuronium


Rocuronium