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6 Cards in this Set
- Front
- Back
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OSTEOBLAST CELL |
-Builds bone -synthesize & deposit fibrous matrix proteins -attract Ca, P to hydroxyapatite -secret alkaline phosphatase to hydrolyze organic phosphate -remove water from matrix as it goes in -if trapped in bones, they become osteocytes: cells that secrete nutrients/ waste in bone |
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OSTEOCLAST CELL |
-reabsorbs bone -attaches to bony surface -secretes acids and enzymes to dissolve bone -releases breakdown of products into fluids around bone |
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BONE REMODELING |
- Replaces damaged bone with new -resorption phase (2-3 weeks) -Mineralization phase |
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Bone Resorption Phase |
-2-3 weeks -lining cells on bone surface retract, expose bone to blood -Osteoclast precursors attach, become osteoclasts, erode bone, die |
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Bone Mineralization Phase |
-2-3 weeks -osteoblasts replace bone to produce lamellar bone -parallel sheets of collagen, strong -mineralization begins 10d later -osteoblasts change to lining cells, protect bone surface |
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Bone Remodeling Cycle |
Pre-osteoclasts-> active osteoclasts_> mononuclear cells_> pre-osteoblasts-> osteocytes |
