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18 Cards in this Set
- Front
- Back
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What are the direct acting noncatecholamine adrenergic agonists?
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PCRAT
-Phenylephrine -Clonidine -Ritodrine -Albuterol -Terbutaline |
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What do all of the noncatecholamine direct acting adrenergic agonists have in common?
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-Insensitive to COMT
-longer T1/2 -Can be given orally |
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What is the receptor selectivity of Phenylephrine? What are its effect?
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a1:
-peripheral vasoconstriction -increased TPR -increased MAP |
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What is Phenlephrine's effect on the heart?
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Decreased heartrate - reflex bradycardia
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What is Phenylephrine's effect on bloodflow?
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Decreased perfusion of most vascular beds
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What has Phenylephrine been used to treat based on its stimulation of reflex bradycardia?
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Atrial arrythmias
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What 3 things is Phenylephrine mainly used for now?
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-Reducing nasal congestion
-Inducing mydriasis for eye exams -Prolonging the effects of local anesthetics |
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What is the receptor selectivity of Clonidine? What is the effect of the action at these receptors?
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CENTRAL a2
-Decreases SNS outflow -Induces bradycardia |
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What 2 drugs act at alpha-2 receptors in the CNS and what are they both used to treat?
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Clonidine and Methyldopa
-Used to treat hypertension |
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What is the receptor selectivity of Ritodrine? What is the effect of the action at these receptors?
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B2
-Relaxes the uterus to delay delivery |
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So what is ritodrine primarily used to treat?
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Pre-term labor
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What receptors are Albuterol and Terbutaline selective for? What effect do they have?
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B2 - bronchodilation
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What are Albuterol/Terbutaline used to treat?
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Asthma
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So to recap, what is the receptor selectivity of PCRAT?
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P - a1
C - a2 central R - B2 AT - B2 |
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3 uses of Phenylephrine
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-Mydriasis
-Nasal decongestant -Local anesthetic prolonger |
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Clonidine
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Antihypertensive (decreased SNS outflow)
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Ritodrine
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Uterine relaxant
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Albuterol/Terbutaline
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Bronchodilation
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