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46 Cards in this Set

  • Front
  • Back
cocaine
inhibits reuptake of NE
amphetamine
displaces / increases release of NE
resperpine
blocks uptake of dopamine into vescicles
haloperidol
dopamine blocker
D2 agonists
Parkinson's disease

(D2 mostly in CNS)
dopamine (low dose)
1. vasodilation in renal vasculature (D1)
dopamine (high dose)
1. vasodilation in renal vasculature (D1)
2. systemic vasoconstriction (alpha-1)

at high doses, dopamine behaves like NE with its added effects on D1 receptors in the kidney
prazosin
alpha 1 blocker
phenylephrine
alpha 1 agonist

1. nasal decongestant
methoxamine
alpha 1 agonist
alpha 1 agonists
1. hypotension
2. nasal decongestant
3. paroxysmal atrial tachycardia
4. eye exam ( cause mydriasis)
5. local vasoconstriction with local anesthetics (dentistry)
6. urinary incontinence
alpha antagonists
1. BPH
2. hypertension
clonidine
alpha 2 agonist

1. HTN - works in the CNS to decrease NE release and decrease sympathetic outflow

remember anything clonidine can do, dexmeditomidine can do better!!!!
dexmedetomidine
alpha 2 agonist - new highly selective alpha 2 agonist

1. HTN
2. sedative in surgery

for hypertension, it decreases sympathetic outflow from the CNS. Does not cause orthostatic hypotension!

don't use too much or it will lose its selectivity and activate alpha-1 causing hypertension, the opposite of the effect you would like to have
dobutamine
beta 1 agonist
beta 1 agonists
1. heart failure (short term)

short term because of beta 1 desensitization and downregulation

S/E tachycardia, hypertension (kidney?), arrhythmias (increase automaticity?)
terbutaline
beta 2 agonist
albuterol
beta 2 agonist
beta 2 agonists
1. asthma (causes bronchodilation)
2. emphysema
3. delay labor

S/E nervousness, headache, tachycardia, palpitations, sweating, and muscle cramps
beta 3 agonists
1. weight loss (increase cAMP and lipolysis in fat cells)
2. heart failure (inotropy) - beta 3 dont downregulate like beta 1
amphetamine
phenylpropanolamine
tyramine
ephedrine
indirect acting sympathomimetic amine
tyramine
decarboxylation product of tyrosine

normally broken down by MAO

can be turned into octopamine, a false NT (which for some reason is released in huge amounts and causes a hypertensive crisis)

MAO inhibitors keep tyramine from being broken down and lead to increased synthesis of octopamine
octopamine
false NT made from tyramine that can cause a hypertensive crisis
phenoxybenzamine
irreversible alpha blocker
phentolamine
alpha blocker

(nonselective b/c it's an imidazoline deriv)
prazosin
alpha 1 blocker

(selective for alpha 1 b/c it's a quinazoline deriv)
trimazosin
alpha 1 blocker

(selective for alpha 1 b/c it's a quinazoline deriv)
ADR of alpha blockers
postural hypotension - alpha 1
tachycarda - BRR
miosis - alpha 1 in radial muscle
nasal stuffiness - alpha 1 in nasal arterioles
failure of ejaculation - cant shoot
receptor specificity of phenoxybenzamine vs phentolamine
phenoxybenzamine - blocks Ach, Histamine, and Serotonin

phentolamine - blocks Ach
mimics histamine and serotonin
uses of alpha blockers
1. hypertension (primary hypertension caused by too much sympathetic outflow only)

2. hypertensive crisis from pheochromocytoma

3. benign prostatic hypertrophy

4. urinary retention?
yohimbine
alpha 2 antagonist

1. clonidine overdose
2. male sexual performance
Propanolol
nonselective beta blocker

propanolol is the very first and prototypical nonselective beta blocker
Timolol
nonselective beta blocker

timolol is an eye drop for ophthalmic use

1. open angled glaucoma
Pindolol
nonselective beta blocker

has ISA activity and is good for congestive heart failure
Nadolol
nonselective beta blocker
Metaprolol
cardioselective beta blocker
Atenolol
cardioselective beta blocker
Acebutalol
cardioselective beta blocker
Uses of beta blockers
1. HTN (blocks Beta 1 mediated renin release from JG cells - this is a long term effect)

2. antiarrhythmic
a. supraventricular arrhythmia (by decreasing AV nodal conductance velocity)
b. PVC
3. Angina (decreases inotropy and HR, decreasing O2 demand)
4. hyperthyroidism (decreases the tachycardia caused by it)
5. open-angled glaucoma (blocks Beta 2 on ciliary body and decreases AH prodn)
6. Anxiety (decreases HR)
7. Migraines (blocks beta 2 receptors in cranial vasculature and thus blocks their vasodilation)
Esmolol
cardioselective beta blocker

short acting
Labetalol
Non-selective 3rd generation beta blocker
Carvedilol
non-selective 3rd generation beta blocker
Celiprolol
cardioselective 3rd generation beta blocker
Betaxolol
cardioselective 3rd generation beta blocker
what are the 2 different types of 3rd generation beta blockers?
labetalol and carvedilol A/E

block alpha 1, beta 1, and beta 2

celiprolol and betaxolol
block beta 1 and alpha 1
they stimulate beta 2

(enhanced vasodilation and good for asthmatics)
which beta blocker decreases mortality
carvedilol - a nonselective 3rd generation beta blocker

blocks alpha 1, beta 1, and beta 2

antioxidant activity

decreases mortality!