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27 Cards in this Set
- Front
- Back
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What is the acronym for catecholamine direct acting agonists?
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Never enter into debt during medical school
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What are the catecholamine direct acting agonists?
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-Norepi
-Epi -Isoproterenol -Dopamine -Dobutamine -Methyldopa |
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What is the acronym for non-catecholamine direct acting agonists?
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PCRAT is not a cat
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What are the non-catecholamine direct acting agonists?
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-Phenylephrine
-Clonidine -Ritodrine -Albuterol -Terbutaline |
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What is the Indirect catecholamine agonist?
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Tyramine
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How do you remember the mixed adrenergic agonists?
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APE is a mix between a human and a monkey
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What are the mixed adrenergic agonists?
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-Amphetamine
-Pseudoephedrine -Ephedrine |
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What are the adrenergic neuron blocker antagonists?
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-Guanethidine
-Reserpine |
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What are the 3 alpha blockers?
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Phe Phe Praz
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What is Phe Phe Praz?
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-Phenoxyenzamine
-Phentolamine -Prazosin |
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How do you remember the B-blockers?
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Props to my boy tim who's a metrosexual eskimo
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What are the B-blockers?
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-Propanolol
-Timolol -Metropolol -Esmolol |
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What is the mixed alpha beta antagonist?
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Carvedilol
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What are the 4 sites of therapeutically relevant a1 adrenergic receptors? What is the response seen at each?
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-Eye - radial m contracts - mydriasis
-Arterioles - contract/incr bp -Veins - contract/incr bp -Sex ejaculate (shoot) |
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What are the 2 sites of therapeutically relevant a2 adrenergic receptors? What is the response seen at each?
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-Presynaptic; inhibits NT release
-Postsynaptic (CNS); inhibits sympathetic outflow |
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What are the 2 therapeutically relevant B1 receptor sites? What is the response to NE seen at each site?
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-Heart - increased HR, conduction velocity, and contractility
-Kidney - increased renin release |
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What are the 5 therapeutically relevant B2 receptor sites? What is the response to NE seen at each site?
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Sk. Muscle arterioles - dilation
Bronchi - dilation Uterus - relaxation Skeletal muscle - glycogenolysis Liver - Glycogenolysis and gluconeogenesis |
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What Gprotein subfamily is for
-A1 -A2 -B1 -B2 |
A1=Gq
A2=Gi B1=Gs B2=Gs |
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What does Gq do?
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Stimulates PLC to convert PIP2 to IP3 + DAG resulting in increased Ca and PKC activity
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What does Gi do?
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Inhibits Adenylyl cyclase which decreases cAMP, decreases Ca influx, and decreases NE release
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What does Gs do?
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Activates Adenylyl cyclase which increases cAMP, increases Ca, stimulates glycogenolysis, and lipase.
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What adrenergic receptors does NE act on?
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A1, A2, and B1
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What are the 3 major cardiovascular effects of NE?
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-Increased diastolic BP
-Increased systolic BP -Reflex bradycardia |
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How does NE increase diastolic bp?
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By causing peripheral vasoconstriction of arterioles and veins which increases TPR
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How does NE increase systolic bp?
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By increasing cardiac contractility
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How does NE stimulate reflex bradycardia?
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When BP increases, the carotid bodies sense it, transmit the signal to CNS, which stimulates the vagus to slow HR back to normal.
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What is the toxic effect of too much NE?
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Neurogenic shock
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