Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
Which of the 5-HT families is ionotrophic?
|
5-HT3
|
|
|
Which family of 5-HT receptors is associated with sleep, thermo-regulation, learning, appetite control, sensory reception and hallucinogens?
|
5-HT2
|
|
|
Which family of 5-HT receptors can be found on a presynaptic neuron?
|
5-HT1 (specifically family D)
|
|
|
Are most 5-HT families ionotrophic or G-protein coupled?
|
G-protein coupled
|
|
|
Is Tryptophan hydroxylase involved in biosynthesis or degradation of serotonin?
|
biosynthesis
|
|
|
Is aromatic amino acid decarboxylase involved in either biosynthesis or degradation of serotonin?
|
biosynthesis
|
|
|
Is Aldehyde/Keto reductase involved in either biosynthesis or degradation of serotonin?
|
degradation
|
|
|
Is aldehyde reductase involved in either biosynthesis or degradation or serotonin?
|
degradation
|
|
|
What is the primary function of 5-HT2A antagonists?
|
Atypical antipsychotics
|
|
|
What effect do many 5-HT2A agonists have?
|
They enhance "tripping rate"
|
|
|
What class of 5-HT drugs do cozapine and risperidone belong to?
|
5-HT2A antagonists
|
|
|
What was the popular drug Fen-Phen used for? What two types of drug was it made up of?
|
Weight loss; 5-HT2c agonist (fenfluramine) + norepinephrine releasing agent (phenteramine)
|
|
|
What do 5-HT3 receptors modulate the release of?
|
Other neurotransmitters like dopamine, Ach, and serotonin
|
|
|
What class of antidepressants is no longer used due to severe side effects?
|
MAO (monoamine oxidase) inhibitors
|
|
|
What are four key structural features of MAO irreversible inhibitors?
|
Hydrazide, hydrazine, terminal alkyne and benzylic cyclopropane
|
|
|
Which isoform of MAO is most closely associated with depression?
|
Isoform B
|
|
|
True or False: All MAO inhibitors bind covalently and thus irreversibly.
|
False.
|
|
|
What are 5-HT3 antagonists used to treat?
|
Nausea.
|
|
|
What is the mechanism of fluoxetine and paroxetine?
|
Serotonin re-uptake inhibitors (SSRI)
|
|
|
Which enzyme would convert imipramine to desipramine, and how does it accomplish this?
|
CYP2D6; dealkylation (removes a methyl group)
|
|
|
What is a proposed mechanism for imipramine to inhibit CYP2D6?
|
The formaldehyde lost may react with the CYP2D6 enzyme, rendering it inactive.
|
|
|
What does SNRI stand for?
|
serotonin norepinephrine reuptake inhibitor
|
|
|
What is an advantage of using SSRIs instead of TCAs?
|
Decreased side effects such as dry mouth, dizziness and cardio-toxicity.
|
|
|
Which group of antidepressants work by attempting to restore both NE and 5-HT without side effects?
|
SNRIs
|
|
|
What is the goal associated with the Biogenic Amine Hypothesis of Depression?
|
The goal is develop drugs that increase overall adrenergic and/or serotonergic levels in the CNS
|
