531 - Med Chem I - Exam Iii - Schizophrenia

Front 1

The hypothesis that overactive dopaminergic transmission in the CNS causes psychosis is known as the ____.

Back 1

Dopamine Hypothesis.

Front 2

An increase in transmission occurs in the (mesolimbic/mesocortical) system in schizophrenia.

Back 2

mesolimbic

Front 3

A decrease in transmission occurs in the (mesolimbic/mesocortical) system in schizophrenia.

Back 3

mesocortical

Front 4

Name some positive symptoms associated with schizophrenia.

Back 4

delusions, hallucinations, disorganized behavior, catatonic behavior

Front 5

Which system are positive symptoms associated with?

Back 5

mesolimibic

Front 6

Name some negative symptoms associated with schizophrenia.

Back 6

affective flattening, alogia and avolition

Front 7

Which system are negative systems associated with?

Back 7

mesocortical

Front 8

Which group of receptors is the mesolimbic system associated with?

Back 8

D2

Front 9

Which group of receptors is the mesocortical system associated with?

Back 9

D1

Front 10

Which receptors are included in the D1 class of receptors?

Back 10

D1, D5

Front 11

Which receptors are included in the D2 class of receptors?

Back 11

D2, D3, D4

Front 12

Which group of receptors (D1 or D2) is associated with stimulatory effects?

Back 12

D1

Front 13

Which group of receptors (D1 or D2) is associated with inhibitory effects?

Back 13

D2

Front 14

What amino acid is dopamine synthesized from?

Back 14

Tyrosine!

Front 15

What are two major enzymes that play a role in dopamine degradation?

Back 15

MAO and COMT

Front 16

Name some D1 antagonists.

Back 16

chloropromazine, haloperidol, clozapine, olanzapine

Front 17

Name some D2 antagonists.

Back 17

chlorpromozine, haloperidol, spiperone, sulpride, risperidone, clozapine, olanzapine

Front 18

Where are D1 receptors located?

Back 18

cortex, limbic system, basal ganglia, hypothalamus

Front 19

Where are D2 receptors located?

Back 19

cortex, limbic system, basal ganglia, pituitary gland

Front 20

Name some EPS.

Back 20

Muscle spasms, tremors, tics, restlessness

Front 21

Which group of antipsychotics are EPS associated with?

Back 21

Typical antipsychotics

Front 22

What are two theories for why atypical antipsychotics don't exhibit EPS?

Back 22

1) They also have 5-HT2 anatagonism.
2) They don't bind to D2 receptors as tightly as typical antipsychotics.

Front 23

What was the initial antipsychotic drug discovered?

Back 23

Chlorpromazine (Thorazine)

Front 24

What two scaffolds do typical antipsychotics combine?

Back 24

TCA and piperazine scaffolds.

Front 25

What are the two primary scaffolds for atypical antipsychotics?

Back 25

1. Benzodiazepines (& isosteres)
2. Arylpiperazines (& isosteres)