Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
____ results in MORE fissuring; formation of sinuses; non-caseating granulomas; strictures; abdominal masses and pain
|
CD
|
|
|
____ results in MORE rectal bleeding; abscesses; toxic megacolon complications; and bowel carcinoma.
|
UC
|
|
|
SEVERE symptoms of UC or CD…
|
Abdominal distention, pain or bloating
Duration of diarrhea Volume losses (severe affect electrolytes) Bleeding from the rectum Infections Ulcers Frequency of symptoms |
|
|
disease state diffs
____ – lifestyle changes may make a great impact ____/____ may be modified and treated with adhering to pharmacotherapy; patient still has some control over risk factors ____– lifestyle changes may not make such a difference; adherence to medications is still important, but patients have less control |
G.E.R.D.
P.U.D. GUD I.B.D. |
|
|
sxs diffs between
UC and CD |
UC - blood, cramps, nausea
“I have blood in my stool!” “I’m feeling tired all day.” “I have cramps in my fingers and toes.” “I’m nauseous…” “I’m feeling anxious about the next attack.” “I don’t want to live anymore.” CD - diahrrhea, malabs “My stomach hurts.” “I go to the bathroom every 2-3 hours.” “I can’t put on any weight.” |
|
|
IBD SX REQ REFERRAL
|
Presence of blood in the stool
Suspecting hypokalemia Suspecting severe anxiety (and not being treated) Suicidal ideation Possible volume depletion Failure to put on weight |
|
|
U.C. can be staged by severity
MILD - MODSEV |
Mild-moderate
Distal colitis (located at the anus) Suppositories/enemas (local TX) + sulfasalazine or balsalazide Local TX + PO TX Extensive colitis Suppositories/enemas (local TX) + sulfasalazine or balsalazide + immune suppressants Severe Require IV medications and systemic treatment Examples: IV hydrocortisone, methylprednisolone, cyclosporine |
|
|
Name, active ingred and properties of the Class these drugs are in...
sulfasalZINE Mesalamine Balsalazide OlsalaZINE |
Aminosalicylates:
active ingrediant that has anti-inflam effects on bowel basteria in GI pH cleaves 5-ASA works in the ILEUM, most others in colon ENEMAS reqd for anal ulcers delivery sys vary |
|
|
Name, active ingred and properties of the Class these drugs are in...
Azathioprine 6-mercaptopurine methotrexate cyclosporine infliximab tacrolimus |
immune modulators
less dosing, may be used as maintenance folic acid deficiency steroid sparing but has SE of hirsutism saved for the end bc causes ↑ resp infection (risk vs. benefit) |
|
|
MOA
Aminosalicylates |
active 5-ASA component has topical anti-inflammatory effects on the bowel; bacteria in the intestine and GI pH cleaves the 5-ASA
|
|
|
MOA
Corticosteroids |
anti-inflammatory and immune-suppressing
|
|
|
MOA
Azathioprine |
metabolized to 6-MP; inhibits DNA synthesis and attenuates immune response
|
|
|
MOA
Methotrexate |
inhibits DHFR (stops purine synthesis) and attenuates immune response
|
|
|
MOA
Cyclosporine |
inhibitor of lymphokine and IL; inhibits T-lymphocytes and T-helper cells
|
|
|
MOA
Infliximab |
recombinant monoclonal antibody that inhibits TNF-dependent IL and inflammatory cytokines
|
|
|
DRAW UC drug tx algorithm
|
|
|
|
DRAW CD drug tx algorithm
|
|
|
|
In the early stages, tx goal is ____, in later stages it's ____
|
remission, get to oral
|
