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18 Cards in this Set

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IL-1
HOT
Secreted by macrophages.

Causes acute inflammation.

Induces chemokine production to recruit leukocytes; activates endothelium to express adhesion molecules.

An endogenous pyrogen.

Goljan: osteoclast activating factor.
IL-2
T
Secreted by helper T cells.

Stimulates growth of helper and cytotoxic T cells.
IL-3
BONE
Secreted by activated T cells.

Supports the growth and differentiation of bone marrow stem cells.

Has a function similar to granulocyte-macrophage colony stimulating factor.
IL-4
stEak
Secreted by Th2 cells.

Promotes growth of B cells.

Enhances class switching to IgE and IgG.
IL-5
steAk
e= 5th letter of the alphabet.
Secreted by Th2 cells. Promotes differentation of B cells.

Enhances class switching to IgA.

Stimulates production and activation of eosinophils. (5th letter of the alphabet)
IL-6
Secreted by Th cells and macrophages.

Major chemotactic factor for neutrophils.
IL-8
Clean up on aisle 8
Secreted by macrophages.

Major chemotactic factor for neutrophils.
IL-10
Secreted by regulatory T cells.

Inhibits actions of activated T cells.

Activates Th2, inhibits Th1.
IL-12
Secreted by B cells and macrophages.

Activates NK and Th1 cells.
gamma-INF
Secreted by Th1 cells.

Stimulates macrophages.

Activates Th1, inhibits Th2.
TNF (Tumor Necrosis Factor)
Secreted by macrophages.

Mediates septic shock.

Causes lekocyte recruitment, vascular leak.
Secreted by macrophages:
IL-1
IL-6
IL-8
IL-12
TNF
Secreted by Th cells:
IL-2
IL-6
Secreted by activated T cells:
IL-3
Secreted by Th2 cells:
IL-4
IL-5
Secreted by regulatory T cells:
IL-10
Secreted by B cells:
IL-12
Secreted by Th1 cells:
gamma-INF