Systemic Inflammation Response Syndrome

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Systemic inflammation response syndrome is a condition that is thought to be a defense mechanism. SIRS is defined by two of the follow characteristics, fever of 38C or less than 36C, HR of 90+, R 20+ or PaCO2 12. SIRS is caused can be caused by ischemia, inflammation, trauma, infection, or a combination of theses. This condition uses inflammation to nonspecific insults to the body.
These insults can be chemical, traumatic, or infectious stimuli. The inflammatory response to the insult begins as a normal response where cytokines initiate the inflammatory response with the goal of wound repair, this is Stage I. In Stage II some of the cytokines are released into circulation to increase the local response. The presence of cytokines stimulate

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