Why Is The Plague So Good At Killing? Essay

1407 Words Apr 16th, 2015 null Page
Why is The Plague SO Good at Killing? There are some factors about the Yersinia pestis that make it an infecting machine. Y. pestis creates two anti-phagocytic antigens, F1 antigen and VW antigen. An anti-phagocytic antigen is defined as, a substance in the immune system’s cells that eats harmful pathogens. Both the F1 and the VW antigen are necessary for the bacteria to grow, as is the temperature, 37degrees Celsius. It is because of this need for a certain temperature, lower than which fleas need to survive, that fleas can act as a vector, or usually a parasite that transmits a disease from one animal or plant to another. This description qualifies the bubonic plague as a zoonotic infection. Another contributing factor that helps Y. pestis overcome phagocytosis is that Y. pestis is capable of inserting macrophages and immune cells with a substance called YOPS, or Yersinia Outer Proteins. Once the YOPS are in the cell, they create pores that allow a passageway for other YOPS to enter the cytoplasm, which further limits phagocytosis. 13 Scientists have recently mapped the gnome for Yersinia pestis and found another reason for its security on the list of dangerously successful diseases. Due to so many genetic exchanges with various microorganisms, there are many irregularities in the genes of Y. pestis that seem to come from those many microorganisms. This evidence appears to suggest that, throughout the millennia of its existence, the plague has endured large-scale…

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