Treatment Of Asthma And Obstructive Pulmonary Disease ( Copd )

739 Words Jun 29th, 2016 3 Pages
Albuterol (also known as Salbutamol) is a medication indicated for the treatment of both asthma and chronic obstructive pulmonary disease (COPD). This agent works by activating 훽2-adrenergic receptors in the lungs, causing bronchodilation and improving airway patency. In the acute care setting, albuterol is often given via nebulization.1,2 The tablet formulation of albuterol exists as well. However, with albuterol having a low systemic bioavailability, ordering albuterol in its tablet form is not appropriate. Therefore, pulmonary drug delivery is typically the preferred route of administration for the treatment of asthma and COPD. Albuterol exhibits a single dose therapy effect.3,4 Once albuterol enters the body, it will change from an out-of-balance effect to within normal bounds. Thus, the feedback control system within the body maintains homeostasis. The correlation between beneficial effect and peak exposure to drug could exist, but beyond the peak, correlation is not likely. This illustrates that albuterol can exert its effect with relatively lower drug doses.
A major advantage of drug delivery via inhalation is the ability to provide doses directly to the lungs which limits systemic side effects. One key factor in drug delivery to the lung is particle size.5 In order for a drug to enter the bronchial tree, the size of the drug particle must range between 1-5 µM. Particles that are less than 1 µM typically remain suspended in the air, while particles that are greater…

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