So you’ve just eaten the greatest peanut butter candy in the world, all of a sudden you get hives and breathing becomes a big issue, your throat is swelling blocking off air. This is what is known as allergic reaction, in this case to peanuts. This is the body’s immune system overreacting to the properties of the peanut. However what causes this phenomenon is a chemical that is called histamine, or if you want to get technical, 2-(1H-imidazol-4-yl)ethanamine. Histamine is active chemical substance that lives in the bodies of most plants and animals, it is also found in insect venom. Its atomic structure is loosely based on the structure of Ammonium. Histamine is formed from amino acid histidine. Histamine was first discovered in 1910 when it was isolated or in other words, picked out of
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It is commonly stored in the granules of the tissues mast cells. Some blood cells also contain histamine. When Histamine is released, Its effect the body ranging from contracting muscles to dilating blood vessels. Histamine also effects acid secretion in the stomach; and the acceleration of heart rate. Histamine also serves to transmit pulses through nerves.
Histamine has two receptors that mainly cause reactions. The first one is called H1 and its responsible for allergic responses. Because of this it normally targeted the most. The H1 receptor increases permeability and stimulates sensory nerves of the nose, it causes sneezing which is common in allergic reactions. The second, the H2 receptor, deals with the smooth muscles in the stomach and the heart. It’s also responsible for the release of T cells that attack pathogens.
Histamine’s receptors H1 and H2 effect on blood vessels is crucial to its role in the immune response, the most common sign that it working is inflammation of cells injured tissue. This releases histamine which allows fluid and cells from the immune system to come in and attack
It is commonly stored in the granules of the tissues mast cells. Some blood cells also contain histamine. When Histamine is released, Its effect the body ranging from contracting muscles to dilating blood vessels. Histamine also effects acid secretion in the stomach; and the acceleration of heart rate. Histamine also serves to transmit pulses through nerves.
Histamine has two receptors that mainly cause reactions. The first one is called H1 and its responsible for allergic responses. Because of this it normally targeted the most. The H1 receptor increases permeability and stimulates sensory nerves of the nose, it causes sneezing which is common in allergic reactions. The second, the H2 receptor, deals with the smooth muscles in the stomach and the heart. It’s also responsible for the release of T cells that attack pathogens.
Histamine’s receptors H1 and H2 effect on blood vessels is crucial to its role in the immune response, the most common sign that it working is inflammation of cells injured tissue. This releases histamine which allows fluid and cells from the immune system to come in and attack