Ethical Issues Outweigh The Disadvantages Of Gene Sequencing?

799 Words 4 Pages
Geneticists have worked towards sequencing the human genome since developing Sanger sequencing in the 1970s. The Human Genome Projected accomplished this in 2003, but now the public wants their own genome sequenced. Some companies have already started performing sequencing for profit. While clinical studies, perform and disclose results genetic sequencing to participants. However, there are scientific, and ethical issues surrounding personal DNA sequencing. Despite this, the advantages outweigh the disadvantages. I would get my gene sequencing because it can illuminate important information. Specifically, I want to know about medically actionable genes, genetic diseases I can develop, early onset brain diseases and if I 'm a carrier of genetic …show more content…
There are many diseases that have some genetics basis. For example, Dr. van der Kooy discussed one cause of blindness via RPE65 proteins. If RPE65 becomes dysfunctional in retinal epithelial cells then vision loss may occur due to a mutated RPE65 gene. Usually, this type of blindness is not detected until vision loss has started. However, this mutation can be detected in a gene sequencing report. Thus susceptible individuals can undergo prophylactic treatment. For example, gene replacement therapy or regeneration of retinal stem cells can maintain vision. As a result, more genes can be classified as medically actionable. This is one of the major reasons I want to undergo gene sequencing. I want to undergo prophylactic treatment of any disease that has a substantial chance in manifesting. However, the reliability of the genetic treatments is questionable. The gene replacement therapy for RPE65 is currently in Phase I/II trials. Thus, it’s not available to the public. Also, stem cell therapy is not currently available for treating RPE65 induced blindness. The use of stem cell therapy is limited to skin grafts and bone marrow transplants. Despite genetic treatments progression, its efficiency still needs to be determined in …show more content…
As mentioned earlier, there is a lot not known about reading and interpreting the genome. Experts have focused on the protein coding region, which encompasses 1% of the human genome. Also, Dr. Szego discussed that having susceptible alleles does not correlate to disease manifestation. The reason behind this phenomenon is unknown. It’s assumed that each variant has an associated small risk. But, more research is required to determine why some variants cause disease and others do not. Finally, a majority of diseases are polygenic thus are only partially affected by genetics. Thus, some individuals can develop these diseases with no genetic predispositions. This complicates the gene variant-disease manifestation relationship is further. The genetic report only discusses disease risk and that can be confusing to understand. Dr. Shuman reported that genetic counselors have received an increase in requests from individuals who underwent Direct to Consumer genetic sequencing. This is why I decided to not have type 2 genes, as categorized by Doc Mike, sequenced. This process is not perfect, but it’s the best genetic technology currently available. Due to its improving quality and valuable information, gene sequencing should be available to the

Related Documents

Related Topics