Asthma And Its Effects On Asthma Essay

733 Words Nov 28th, 2015 3 Pages

Asthma is one of the most prevalent chronic diseases worldwide characterized by the inflammation of the bronchial smooth muscles. In the past 20 years, the incidence of asthma, especially in children, has increased (Wong et al., 2009). Inflammatory and structural changes of asthma in the airways lead to narrowing of the airway, edema as increased mucus production and bronchoconstriction. While bronchoconstriction plays a key role in asthma, more emphasis has recently been placed on the inflammatory response. The inflammatory response is an overreaction to numerous triggers including allergens (pollens, mold spores, pet dander, and dust mites), irritants (perfumes, cleaning solutions, and air pollution), tobacco smoke, change in temperature, anxiety, and exercise (Srivastava, Zhang, Yang, Sampson, & Li, 2010).

In asthma, chronic inflammation is the result of intricate interactions of numerous cells. The inflammation is caused by eosinophils, lymphocytes, mast cells, and phagocytes that invade the cell in response to triggers causing epithelial injury. Asthma inflammation is a series of events that include: sensitization, stimulation, cell signaling, inflammatory cell migration, activation of inflammatory cells, and airway remodeling. This is known as the inflammatory cascade. In response to an allergen, the body produces immune cells such as T-cells, B-cells, IgE, and mast cells. Mast cells then release inflammatory mediators such as histamine, leukotrienes, and…

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