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5 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Retrovirus
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23% use in clinical trials
7 kb insert, used ex vivo |
A: stable integration, efficient
D: infects dividing cells only, random integration |
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Lentivirus
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0.8% use in clinical trials
7 kb insert, HIV |
A: no host immune response, stable integration
D: not widely used |
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Herpesvirus
|
3.2% use in clinical trials
150 kb insert, targets neuronal cells |
A: infects non-dividing cells, large genome
D: not widely used, possible expression latency |
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Adenovirus (AD)
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25% use in clinical trials
30 kb insert |
A: easy to prepare, infects non-dividing cells
D: does not integrate into host genome, stimulates immune response |
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Adeno-associated virus (AAV)
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4.0% use in clinical trials
4.5 kb insert, stable integration at chromosome 19 |
A: stable integration, non-pathogenic
D: difficult to prepare, small genome=small inserts |
