Usmle Step 1 Fa Immunology-Inflammation

Front 1

Neutrophil chemotaxis cytokines/molecules

Back 1

IL-8, C5a, leukotrience B4 (endothelial damage) , fibrinopeptides (from endothelial damage), formyl methyionyl peptides (released from microorganisms)

Front 2

Histamine
(a) source
(b) effects during inflammation
(c) triggers for release

Back 2

(a) basophils, mast cells, platelets
(b) vasodilation, increased vascular permeability

Front 3

Serotonin
(a) source
(b) effects
(c) triggers for release

Back 3

(a) platelets
(b) vasodilation and increased vascular permeability
(c) platelet aggregation

Front 4

Thromboxane A2
(a) produced by what enzyme?
(b) effect?

Back 4

(a) cylcooxygenase (arachadonic acid product)
(b) vasoconstriction and platelet aggregation (made by platelets)

Front 5

Prostacylin (PGI2)
(a) produced by what enzyme?
(b) effect?

Back 5

(a) cyclooxygenase (arachadonic acid product)
(b) vasodilation and inhibits platelet aggregation (made by vascular endothelium)

Front 6

PGE2
(a) produced by what enzymes?
(b) effect?

Back 6

(a) cyclooxygenase (arachadonic acid product)
(b) pain

Front 7

PGE2, PGD2, PGF2
(a) produced by what enzyme?
(b) effect?

Back 7

(a) COX (arachadonic acid product)
(b) vasodilation

Front 8

LTB4
(a) produced by what enzyme?
(b) effect?

Back 8

(a) lipooxygenase
(b) neutrophil chemotaxis, increased vascular permeability, vasoconstriction or vasodilation

Front 9

LTC4, LTD4, LTE4
(a) produced by what enzyme?
(b) effect?

Back 9

(a) lipooxygenase
(b) bronchoconstriction, increased vascular permeability, vasoconstriction or dilation (tissue specific-constriction in kidney and heart and vasodilation in skin and nasal mucosa)

Front 10

Bradykinin
(a) describe production
(b) effect
(c) degraded by?

Back 10

(a) Hageman factor (XII) converts prekallikrein to kallikrein which converts kininogen to bradykinin
(b) increased vascular permeability, pain, vasodilation, bronchodilation
(c) various peptidases including angiotensin converting enzyme