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4 Cards in this Set
- Front
- Back
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Systemic lupus erythematosus
(a)description (b) autoantibodies (c) clinical features (d) comments (e) treatment |
(a) chronic systemic autoimmune disease characterized by a loss of self tolerance and production of autoantibodies
(b) Antinuclear Ab 95% -Anti dsDNA (40-60) -Anti Sm (20-30) (c) Hemolytic anemia, thrombocytopenia, leukopenia -arthritis -skin rashes (including malar) -renal disease -libman sacks endocarditis -neurologic sx (d) F>>>M, peak 20-35YO, AA>caucasion -Type II and III hypersentivity rxns (e) Steroids and other immunosuppressants |
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Sjogren syndrome
(a)description (b) autoantibodies (c) clinical features (d) comments |
(a) an autoimmune disease characterized by destruction of the lacrimal and salivary glands, resulting in the inability to produce saliva or tears
(b) antiribonucleoprotein antibodies: Anti SS-A (Ro) Anti SS-B (La) (c) -Keratoconjunctivitis sicca (dry eyes) and corneal ulcers -Xerostomia (dry mouth) -Mikulcz syndrome; enlargement of the salivary and lacrimal glands (d) F>M, age range 30-50YO -often assoc w/RA and other autoimmune dz -increased risk of lymphoma |
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Scleroderma (diffuse)
(a)description (b) autoantibodies (c) clinical features (d) comments (e) treatment |
(a) Chracterized by fibroblast stimulation and desposition of collagin skin and internal organs. Activation of fibroblasts by FG's.cytokines leads to fibrosis.
(b) Anti DNA topoisomerase I ab (Scl-70) (c) Widespread skin involvement and early involvement of visceral organs -Esophagus (dysphagia) -GI tract (malabsorption) -Pulmonary fibrosis (dyspnea on exertion) -Cardiac fibrosis (arrhythmias) -Kidney fibrosis (renal insufficiency) Raynaud's phenomenon seen in almost all and often preceeds other symptoms. (d) F>M age 20-55YO (e) vasodilators, ACEI, NSAIDs, steroids, d-penicillamine |
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Scleroderma (limited)
(a)description (b) autoantibodies (c) clinical features (d) comments (e) treatment |
a) Chracterized by fibroblast stimulation and desposition of collagin skin and internal organs. Activation of fibroblasts by FG's.cytokines leads to fibrosis.
(b) anticentromere antibodies (c) skin involvement in hand and face; late involkvement of visceral organs (relatively benign course) (d) CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) |
