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20 Cards in this Set
- Front
- Back
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What is the m.o.a of vincristine and vinblastine? toxic side effects?
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M-phase specific alkaloids that bins to tubulin and block polymerization of microtubules so that mitotic spindle can't form
toxic vincristine: neurotox (areflexia, peripheral neuritis), paralytic ileus vinblastin: blasts bone marrow (suppression), aplastic anemia |
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pt with recente weakness, pallor, craving ice chips and tachy with hx of gastritis. What do you immed suspect of cause of pts anemia and how do you tx it?
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pernicous anemia
tx: B12 |
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pt develps hypercalcemia from most common nonmetastatic tumor arising within bones in adults. lab finidn?
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multiple myeloma: CRAB anemia, hypercalcemia, renal insuff, bone/back pain
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Which types of infection are macrolide antibiotics good choice. MCC of non-adherence to marolide antibiotics?
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good for: URI, pnumonias STD, mycoplasma, legionella, chlamydia, Neisseria
non adherence due to GI discomfort |
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What is endometriosis? Classical gross appearance?
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non-neoplastic endometrial glands/stroam in abnormal locations outside the uterus;
appearance: blood filled chocolate cysts |
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Which type of DM fits:
*a/w obesity *may cause ketoacidosis *strong genetic predisposition *a/w HLA DR 3 and 4 |
obesity: II
KA: I genetic: II HLA DR 3, 4: I |
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What are the most common locatins of lung cancer mets?
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Brain- epilepsy
Liver: jaundice, hepatomegaly bone: path, fracture |
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How would resistance throug a 6cm vessel differ from the resistance throuhg multiple vessels with a collective diameter of 36cm (all factors equal)
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Resistance is directly prop to viscosity and inversly prop to radius to the 4th power. Therefore the vessel with radius of 3 has 6x more resistance than the one diwht 18cm radius
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58 y/o pt had hysterectomy. Recieve's pain med via PCA pump. 8 hrs later you are paged for resp depression. What med will cure resp depression?
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pts is on opiods.
To reverse use Naloxone or Naltrexone |
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What are the early cyanotic heart dz? late cyanotic?
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early: TOF, Transposition, tricuspid atresia, truncus arterious, TAPVR
late: VSD, ASD, PDA |
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Where is the motor innervation to the legs located in the lat. corticospinal tract?:
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legs are lateral in the LCS tract
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Which brachail arch has derivative that begin with S. what are the derivatives?
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Branchial Arch 2 (Reichert's cartilage): Stapes, styloid process, Stylohyoid ligament.
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What ist the structure of HbH? What dz results in HbH production? what is the structure of Hb Barts? what dz results from Hb Barts production?
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HbH: B4 tetramer lacking 3 alpha globin chains. dz - alpha thallassemia
Hb Barts; beta4 tetramers, lacks all 4 alpha globin results in hydrops fetalis and intrauterine fetal death |
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What is the underlying cause of hereditary spherocytosis? What microscopic finidng and lab values would you suspect?
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hemolysis due to ankryin band 3.1 or spectrin defect.
findings: RBC are small and round with not central pallor |
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What are the sites of fetal erythropoeisis?
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Yolk sac: 3-8wks
Liver: 6-30 wks Spleen: 9-28wks Bone marrow: 28wks |
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Which carboxylation reaction is used as biotin as a cofactor?
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acetyl-coA carboxylase: acetyl coA --> malonly coA
propionyl-co a carboxylase: Propionyl --methylmalonyl coA pyruvate carboxylase: pyruvate --> OAA |
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How can you determine whether hypoglycemia is caused by endogenous abnromality (such as insulinoma) or by exogenous insuling uptake?
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serum C peptide is not present with exogenous insulin uptake
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What non addctive med can be used in the tx of generalized anxiety disorder?
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Buspirone (5HT1a R stimulator)
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What are the criteria for dx substance dependence:
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3+ of the following:
tolerance withdrawal substance taken in large amts or over a long per of time peristent desire or unsuccessful attempt to cut down signifant energy spent obatining, using or recovering from sustance important social, occupational or recreatinonal activities reduced becasue of substance use Conintue us in spite of knowing the problems that ic causes |
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What is the current drug of choice for both avian and swine influenza
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Zanamivir and Oseltavmivir
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